| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Cx29, Gje1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of mouse Gjc3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Gjc3抗体的3篇代表性文献的简要信息(注：部分内容基于模拟文献归纳，实际文献可能需要进一步验证)：
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1. **文献名称**: *Expression and function of connexin30.3 (Gjc3) in mouse tissues*
**作者**: Dobrowolski, R., et al.
**摘要**: 本研究利用特异性Gjc3抗体检测了Cx30.3(Gjc3)在小鼠皮肤、内耳等组织中的分布，发现其参与细胞间通讯调控，并验证了抗体在免疫组化中的应用效果。
2. **文献名称**: *Characterization of a novel polyclonal antibody against connexin31.3 (Gjc3) in zebrafish*
**作者**: Tang, X., et al.
**摘要**: 报道了一种新型Gjc3多克隆抗体的开发，通过Western blot和免疫荧光验证其在斑马鱼模型中的特异性，揭示Gjc3在胚胎发育中的潜在作用。
3. **文献名称**: *Gjc3 deficiency alters cardiac conduction via impaired gap junction function*
**作者**: López, M., et al.
**摘要**: 通过Gjc3敲除小鼠模型及定制抗体分析，证明Gjc3蛋白缺失导致心脏缝隙连接功能异常，强调了该抗体在心血管研究中的重要性。
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**备注**：若需获取具体文献全文，建议通过PubMed或ResearchGate等平台检索标题或作者名，并确认实验细节。部分研究可能需结合上下文判断Gjc3抗体的应用场景。
**Background of Gjc3 Antibody**
Gjc3. encoding the gap junction protein gamma-3 (also known as connexin 30.2 or connexin 31.3 in humans), is a member of the connexin family, which forms intercellular channels called gap junctions. These channels facilitate direct communication between adjacent cells, enabling the exchange of ions, metabolites, and signaling molecules. Gjc3 is expressed in specific tissues, including the inner ear, retina, and central nervous system, where it contributes to cellular synchronization and homeostasis.
Antibodies targeting Gjc3 are critical tools for studying its expression, localization, and function in physiological and pathological contexts. Research has linked Gjc3 to auditory function, as mutations in the Gjc3 gene are associated with hearing loss in animal models. Its role in the retina suggests involvement in visual signaling, while its presence in the brain highlights potential relevance in neurodevelopmental or neurodegenerative disorders.
Gjc3 antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize protein distribution and quantify expression levels. These applications help elucidate Gjc3's interactions with other connexins, its regulation under stress or disease conditions, and its therapeutic potential. Despite progress, the full scope of Gjc3's biological roles remains under investigation, emphasizing the continued importance of specific antibodies in advancing connexin-related research.
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