| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/10000 | Human,Mouse,Rat |
| Aliases | ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NECTIN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NECTIN1抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *NECTIN1 as a Biomarker for HPV-Associated Oropharyngeal Cancer*
**作者**: Pickard, R.K.L., et al.
**摘要**: 研究揭示了NECTIN1在HPV阳性口咽癌中的高表达，并开发了一种特异性抗体用于免疫组化检测。该抗体在区分HPV相关肿瘤与非病毒性癌症中显示出潜在诊断价值。
2. **文献名称**: *Targeting NECTIN1 in Triple-Negative Breast Cancer with Monoclonal Antibody Therapy*
**作者**: Takano, A., et al.
**摘要**: 报道了一种靶向NECTIN1的单克隆抗体，通过抑制NECTIN1与EGFR的相互作用阻断下游信号通路，在TNBC小鼠模型中显著抑制肿瘤生长和转移。
3. **文献名称**: *Structural Basis of Nectin-1 Recognition by Herpes Simplex Virus Glycoprotein D*
**作者**: Zhang, N., et al.
**摘要**: 利用抗NECTIN1抗体解析了HSV-1病毒糖蛋白D与NECTIN1的结合表位，揭示了病毒感染机制，为基于受体阻断的抗体药物开发提供结构生物学依据。
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注：以上为模拟摘要，实际文献需通过PubMed/Google Scholar检索关键词“NECTIN1 antibody”获取。
The NECTIN1 antibody targets Nectin-1. a cell adhesion molecule belonging to the Nectin family, which plays a critical role in forming and maintaining adherens and tight junctions in epithelial and endothelial cells. Nectin-1 (encoded by the *PVRL1* gene) consists of an extracellular region with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail that interacts with afadin, facilitating connections to the actin cytoskeleton. Beyond structural roles, Nectin-1 serves as a receptor for herpes simplex virus (HSV) entry into cells, highlighting its significance in viral pathogenesis.
NECTIN1 antibodies are essential tools in biomedical research, enabling the detection, localization, and functional analysis of Nectin-1 in tissues and cultured cells. They are widely used in techniques like immunohistochemistry, flow cytometry, and Western blotting to study Nectin-1's expression patterns in normal physiology and diseases, including cancer, where aberrant Nectin-1 levels correlate with tumor progression or suppression. Additionally, these antibodies aid in exploring Nectin-1's involvement in neurological disorders and immune responses. Therapeutic applications are also emerging, with antibodies targeting Nectin-1 being investigated for blocking HSV infection or modulating cell adhesion in wound healing. Monoclonal NECTIN1 antibodies offer high specificity, while polyclonal variants provide broader epitope recognition, catering to diverse experimental needs. Overall, NECTIN1 antibodies are pivotal in unraveling the protein's dual roles in cellular homeostasis and disease pathways.
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