Rabbit Polyclonal LRP2 Antibody

The LRP2 antibody targets the low-density lipoprotein receptor-related protein 2 (LRP2), also known as megalin, a multi-ligand endocytic receptor critical for cellular uptake of various biomolecules. LRP2 is a large transmembrane glycoprotein belonging to the LDL receptor family, characterized by ligand-binding cysteine-rich repeats, epidermal growth factor (EGF)-like domains, and a cytoplasmic tail mediating intracellular signaling. It is predominantly expressed in polarized epithelial cells, including renal proximal tubules, lung alveoli, and the blood-brain barrier, where it facilitates the reabsorption of vitamins, hormones, and lipoproteins. Dysregulation of LRP2 is linked to renal pathologies (e.g., diabetic nephropathy), neurodegenerative disorders, and cancers due to its role in nutrient sensing and signaling. Antibodies against LRP2 are essential tools for studying its expression, localization, and function in physiological and disease contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate LRP2's involvement in proteinuria, vitamin metabolism, and receptor-mediated endocytosis. Additionally, LRP2 antibodies have diagnostic potential in identifying tissue-specific biomarkers and therapeutic targets, particularly in renal and metabolic diseases. Research continues to explore its interactions with ligands like apolipoproteins and signaling pathways, underscoring its significance in cellular homeostasis.