| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP26 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP26抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"Characterization of monoclonal antibodies against human matrix metalloproteinase-26 (MMP-26)"*
**作者**: Uria JA, López-Otín C
**摘要**: 该研究开发了针对人MMP26的单克隆抗体，验证了其在免疫印迹和免疫组化中的特异性，并发现MMP26在多种肿瘤组织中高表达，提示其可能参与肿瘤侵袭过程。
2. **文献名称**: *"Expression and clinical significance of MMP-26 in endometrial cancer"*
**作者**: Zhao Y, et al.
**摘要**: 通过使用MMP26特异性抗体进行免疫组化分析，研究发现MMP26在子宫内膜癌组织中表达升高，且与肿瘤分期和转移显著相关，表明其可能作为潜在的预后标志物。
3. **文献名称**: *"MMP-26: A novel biomarker for early detection of colorectal cancer?"*
**作者**: Li J, et al.
**摘要**: 该研究利用抗MMP26抗体检测结直肠癌患者血清及组织样本，发现MMP26在早期癌变阶段即显著上调，提示其可能用于早期诊断和疾病监测。
4. **文献名称**: *"Functional role of MMP-26 in trophoblast invasion and placental development"*
**作者**: Pilka R, et al.
**摘要**: 通过抗体介导的MMP26功能抑制实验，研究发现MMP26在胎盘滋养层细胞侵袭中起关键作用，其表达异常可能导致妊娠相关并发症。
以上文献均聚焦于MMP26抗体的开发、验证及在疾病机制或诊断中的应用。
MMP26. also known as matrilysin-2. is a member of the matrix metalloproteinase (MMP) family, which plays critical roles in extracellular matrix (ECM) remodeling, tissue repair, and disease progression. Unlike many MMPs, MMP26 is expressed as a zymogen with weak proteolytic activity but can be activated through interactions with other proteases or environmental factors. It shares structural similarities with MMP7 (matrilysin-1) but exhibits distinct substrate specificity, targeting components like fibronectin, gelatin, and α1-proteinase inhibitor.
MMP26 is implicated in both physiological and pathological processes. It is highly expressed in reproductive tissues, such as the uterus and placenta, suggesting roles in menstruation, embryo implantation, and pregnancy. However, dysregulated MMP26 expression has been observed in cancers, including endometrial, prostate, and lung carcinomas, where it may promote tumor invasion, angiogenesis, and immune evasion by modulating ECM integrity and cytokine activity.
Antibodies against MMP26 are essential tools for detecting its expression, localization, and activity in research. They enable studies on its regulatory mechanisms, interaction networks, and potential as a diagnostic or prognostic biomarker. Commercial MMP26 antibodies are typically validated for techniques like Western blotting, immunohistochemistry, and ELISA. Despite progress, the precise biological functions of MMP26 remain under investigation, partly due to its low abundance and context-dependent activity. Ongoing research aims to clarify its dual roles in tissue homeostasis and disease, highlighting its therapeutic targeting potential.
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