| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NTR2 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NTSR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NTSR2抗体的3篇参考文献示例(注：文献为模拟示例，实际引用需核实)：
1. **文献名称**：*Development of a monoclonal antibody targeting NTSR2 for neuroendocrine tumor imaging*
**作者**：Smith A, et al.
**摘要**：研究团队开发了一种靶向NTSR2的单克隆抗体，通过体外和体内实验验证其特异性，并证明其在神经内分泌肿瘤模型中可用于分子影像学检测。
2. **文献名称**：*NTSR2 expression in glioblastoma and its therapeutic implications*
**作者**：Chen L, et al.
**摘要**：该研究利用抗NTSR2抗体分析胶质母细胞瘤中受体的表达水平，发现高表达NTSR2与患者预后不良相关，提示其可能成为治疗靶点。
3. **文献名称**：*Characterization of a novel anti-NTSR2 antibody for studying receptor localization in the central nervous system*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型兔源多克隆抗体的制备与验证，该抗体能特异性识别小鼠和人类NTSR2.成功应用于脑组织切片中受体的免疫组化定位分析。
如需具体文献，建议通过PubMed或Google Scholar以“NTSR2 antibody”为关键词检索近年研究。
The neurotensin receptor type 2 (NTSR2) is a G protein-coupled receptor (GPCR) that binds neurotensin, a 13-amino-acid neuropeptide involved in modulating pain perception, dopamine signaling, and inflammatory responses. Unlike NTSR1. which has high affinity for neurotensin, NTSR2 exhibits lower ligand-binding affinity and distinct tissue distribution, primarily localizing to the central nervous system (CNS), including the brain and spinal cord, as well as peripheral tissues like the gastrointestinal tract and immune cells.
NTSR2 has gained attention for its potential roles in pathological conditions. Studies suggest its involvement in neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s), chronic pain, and cancer progression. In oncology, NTSR2 is overexpressed in certain tumors, such as glioblastoma and pancreatic cancer, where it may promote cell proliferation, migration, and survival. This receptor has also been linked to neuroinflammation, interacting with microglia and astrocytes to regulate immune responses in CNS disorders.
NTSR2 antibodies are critical tools for investigating receptor expression, activation mechanisms, and downstream signaling pathways. They enable the detection of NTSR2 in tissues or cell lines via techniques like immunohistochemistry, Western blotting, or flow cytometry. Additionally, therapeutic NTSR2-targeting antibodies are being explored to modulate receptor activity in diseases, though challenges remain in achieving specificity and minimizing off-target effects due to structural similarities among GPCRs. Ongoing research aims to clarify NTSR2's precise biological functions and its viability as a diagnostic or therapeutic target.
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