| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B |
| WB Predicted band size | 166 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GRIN2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于GRIN2B抗体的参考文献概览(基于近年研究整理，非真实文献，仅示例格式)：
---
1. **文献名称**: *GRIN2B antibody validation for synaptic protein quantification in autism models*
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫组化验证了商业GRIN2B抗体的特异性，发现其在自闭症小鼠模型海马组织中可准确检测GRIN2B蛋白表达下调，提示其在神经突触功能研究中的应用价值。
2. **文献名称**: *Autoantibodies against GRIN2B in autoimmune encephalitis: Clinical correlates*
**作者**: Lee J, et al.
**摘要**: 报道了在自身免疫性脑炎患者血清中发现抗GRIN2B抗体，并通过细胞实验证实其干扰NMDA受体功能，可能与患者认知障碍和癫痫发作相关。
3. **文献名称**: *GRIN2B antibody-based imaging probes for tracking glutamate receptor dynamics in vivo*
**作者**: Chen X, et al.
**摘要**: 开发了一种基于GRIN2B抗体的新型近红外成像探针，成功应用于活体小鼠脑部NMDA受体分布的实时可视化，为神经退行性疾病研究提供工具。
---
(注：以上为模拟示例，实际文献需通过PubMed/Google Scholar以关键词"GRIN2B antibody"检索。)
The GRIN2B antibody is a crucial tool in neuroscience research, targeting the GluN2B subunit of the NMDA (N-methyl-D-aspartate) receptor, a ligand-gated ion channel central to synaptic plasticity, learning, and memory. The GRIN2B gene encodes the GluN2B protein, which combines with GluN1 subunits to form functional NMDA receptors. These receptors mediate excitatory neurotransmission and calcium influx, playing pivotal roles in brain development and cognitive functions.
GRIN2B antibodies are widely used to detect and quantify GluN2B expression in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. Their applications span studies on neurodevelopmental disorders (e.g., autism, intellectual disability), neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions linked to NMDA receptor dysfunction. Mutations in GRIN2B are associated with altered receptor activity, making these antibodies valuable for characterizing disease mechanisms or evaluating therapeutic interventions.
Research using GRIN2B antibodies has revealed the subunit’s unique features, such as its high calcium permeability, sensitivity to ifenprodil (a selective antagonist), and role in synaptic maturation. The antibody also aids in mapping GluN2B distribution in brain regions like the hippocampus and cortex, highlighting its regional and developmental expression patterns. As NMDA receptors are therapeutic targets, GRIN2B antibodies contribute to drug discovery and preclinical validation, bridging molecular insights with clinical applications.
×
