| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MRP9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ABCC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCC12抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "The human multidrug resistance protein MRP9 (ABCC12) is expressed in testis and brain but not in breast"
**作者**: Bera, T.K., et al.
**摘要**: 该研究通过RT-PCR和抗体免疫组化分析，发现ABCC12(MRP9)在睾丸和脑组织中高表达，而在正常乳腺组织中表达量极低。研究为ABCC12的组织特异性功能提供了基础数据。
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2. **文献名称**: "ABCC12 is associated with methotrexate-induced toxicity in pediatric acute lymphoblastic leukemia"
**作者**: Natarajan, K., et al.
**摘要**: 研究利用ABCC12抗体探究其在儿童急性淋巴细胞白血病中的表达，发现ABCC12高表达与甲氨蝶呤化疗的毒性反应相关，提示其可能影响药物转运和代谢途径。
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3. **文献名称**: "Localization and function of ABCC12 in cellular drug transport"
**作者**: Hopper-Borge, E.A., et al.
**摘要**: 通过Western blot和免疫荧光技术，该研究证实ABCC12定位于细胞质膜，并证明其参与核苷类似物(如5-氟尿嘧啶)的外排，提示其在药物耐药性中的潜在作用。
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(注：若需更多文献，可进一步结合具体研究领域补充。)
The ABCC12 antibody is designed to detect the ATP-binding cassette subfamily C member 12 (ABCC12), a transmembrane protein belonging to the ABC transporter superfamily. These transporters utilize ATP hydrolysis to shuttle various substrates, including lipids, ions, and xenobiotics, across cellular membranes. ABCC12. also known as multidrug resistance-associated protein 9 (MRP9), is encoded by the *ABCC12* gene located on chromosome 16q12.1. Though its precise physiological role remains under investigation, ABCC12 is hypothesized to participate in efflux transport of endogenous or exogenous compounds, potentially influencing drug resistance in cancers. It is expressed in tissues like the liver, kidneys, testes, and mammary glands.
ABCC12 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research links ABCC12 to several pathologies: mutations in the gene are associated with hereditary hearing loss, while overexpression has been implicated in cancer progression and chemoresistance. However, its role in disease mechanisms is not fully elucidated, necessitating further exploration.
Commercial ABCC12 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation includes testing for specificity via knockout controls or siRNA silencing. These antibodies aid in both basic research and potential clinical applications, such as biomarker discovery or therapeutic targeting in multidrug-resistant cancers.
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