| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HARP, HBNF, HBGF8, NEGF1 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PTN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTN(多效生长因子，Pleiotrophin)抗体的参考文献示例(内容为模拟概括，非真实文献)：
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1. **《Pleiotrophin as a Biomarker in Glioblastoma: Development of a Novel PTN-Specific Antibody》**
- 作者：Smith A, et al.
- 摘要：研究开发了一种高特异性PTN单克隆抗体，用于检测胶质母细胞瘤组织中PTN的过表达，证实其与肿瘤侵袭性和患者预后的相关性，为PTN作为癌症诊断标志物提供工具。
2. **《Targeting PTN with Neutralizing Antibodies Inhibits Tumor Angiogenesis in a Mouse Model》**
- 作者：Chen L, et al.
- 摘要：通过中和性PTN抗体阻断PTN信号通路，显著抑制小鼠模型中肿瘤血管生成和转移，表明PTN抗体在抗肿瘤治疗中的潜在应用价值。
3. **《PTN Antibody-Based Therapy Promotes Neuronal Regeneration in Spinal Cord Injury》**
- 作者：Wang Y, et al.
- 摘要：研究利用PTN抗体调节中枢神经系统微环境，促进脊髓损伤后的轴突再生和功能恢复，揭示了PTN在神经修复中的双重作用及抗体干预策略。
4. **《A High-Affinity PTN Antibody for ELISA-Based Detection in Serum Samples》**
- 作者：Garcia R, et al.
- 摘要：报道了一种基于PTN抗体的ELISA检测方法，用于定量分析血清中PTN水平，验证其在炎症性疾病和癌症早期筛查中的临床应用潜力。
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建议通过PubMed或Google Scholar搜索关键词“Pleiotrophin antibody”、“PTN therapeutic antibody”等获取真实文献。
Pleiotrophin (PTN), also known as heparin-binding growth-associated molecule (HB-GAM), is a secreted cytokine belonging to the neurite growth-promoting factor family. First identified in the 1980s, PTN plays critical roles in embryonic development, tissue repair, and pathological processes such as tumorigenesis. It binds to cell surface receptors like receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and integrins, activating downstream signaling pathways (e.g., PI3K/AKT, MAPK) that regulate cell proliferation, migration, angiogenesis, and stem cell differentiation.
PTN overexpression is linked to various cancers, including glioblastoma, melanoma, and breast cancer, where it promotes tumor growth, metastasis, and resistance to therapy. It also contributes to neurodegenerative diseases and inflammatory conditions. PTN antibodies, either monoclonal or polyclonal, are essential research tools for detecting PTN expression in tissues or serum, elucidating its biological functions, and validating its role in disease mechanisms.
Therapeutic PTN-targeting antibodies are under investigation to block PTN-receptor interactions, aiming to inhibit tumor progression or modulate tissue regeneration. Challenges include optimizing antibody specificity and delivery, as PTN’s pleiotropic effects involve complex interactions within the extracellular matrix. Recent studies also explore PTN as a biomarker for cancer prognosis. Overall, PTN antibodies hold promise for both basic research and translational applications in oncology and regenerative medicine.
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