| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HsT18964 |
| WB Predicted band size | 133 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ITGA11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGA11抗体的3篇参考文献示例(文献信息为虚拟示例，仅作格式参考)：
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1. **文献名称**: *Integrin α11β1 regulates cancer-associated fibroblast heterogeneity in tumor microenvironment*
**作者**: Smith J, et al.
**摘要**: 研究利用ITGA11特异性抗体，通过免疫组化和流式细胞术分析肿瘤微环境中癌症相关成纤维细胞的异质性，发现ITGA11高表达与胶原重塑和患者预后不良相关。
2. **文献名称**: *Targeting ITGA11 in fibrosis: A monoclonal antibody approach to inhibit collagen signaling*
**作者**: Lee S, et al.
**摘要**: 开发了一种阻断性抗ITGA11单克隆抗体，在小鼠肺纤维化模型中证实其可通过抑制整合素-胶原信号通路减轻纤维化病变，为治疗纤维化疾病提供潜在策略。
3. **文献名称**: *ITGA11 as a novel biomarker in triple-negative breast cancer: Antibody-based detection and functional validation*
**作者**: Zhang Y, et al.
**摘要**: 使用ITGA11抗体进行Western blot和免疫荧光检测，发现ITGA11在三阴性乳腺癌中特异性高表达，并通过抗体阻断实验证明其促进肿瘤细胞迁移的机制。
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注：以上文献为示例，实际文献需通过PubMed或Web of Science等平台以关键词“ITGA11 antibody”检索确认。
The ITGA11 antibody targets integrin alpha-11 (ITGA11), a transmembrane glycoprotein that pairs with integrin beta-1 (ITGB1) to form the α11β1 collagen receptor. ITGA11 is a member of the integrin family, which mediates cell-extracellular matrix (ECM) interactions, influencing cellular adhesion, migration, and signaling. Specifically, α11β1 binds collagen types IV and VI, playing roles in tissue development, wound healing, and fibrosis. ITGA11 is highly expressed in mesenchymal stromal cells, fibroblasts, and certain cancers, where it contributes to tumor progression, stromal remodeling, and metastasis.
Research on ITGA11 antibodies has gained momentum due to their potential applications in studying fibrosis and cancer biology. In fibrotic diseases (e.g., lung or liver fibrosis), ITGA11 overexpression correlates with excessive collagen deposition and tissue stiffening. In cancers, ITGA11 promotes invasion and angiogenesis by modulating tumor-stroma crosstalk. Antibodies against ITGA11 enable detection of its expression in tissues (via IHC, IF, or flow cytometry) or functional blocking in vitro/in vivo models to dissect its mechanistic roles.
Commercial ITGA11 antibodies are typically monoclonal or polyclonal, validated for specificity in human, mouse, or rat samples. Their development supports translational studies exploring ITGA11 as a diagnostic biomarker or therapeutic target. However, challenges remain in standardizing antibody validation and understanding isoform-specific functions. Ongoing research aims to clarify ITGA11's dual roles in homeostasis and pathology, driving interest in targeted therapies for fibrosis and cancer.
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