| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ATG24A |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SNX30 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SNX30抗体的示例参考文献(注：以下文献信息为示例性虚构内容，实际引用时请核实真实文献)：
---
1. **文献名称**：*"A Monoclonal Antibody Targeting SNX30 Reveals Its Role in Endosomal Sorting"*
**作者**：Zhang, L. et al.
**摘要**：本研究开发了一种特异性识别SNX30蛋白的单克隆抗体，验证了其在免疫印迹和免疫荧光中的应用。结果表明，SNX30通过其PX结构域与内体膜结合，调控EGFR等受体的分选过程。
2. **文献名称**：*"SNX30 Antibody-Based Profiling Identifies Dysregulation in Neurodegenerative Models"*
**作者**：Kim, S. & Patel, R.
**摘要**：利用兔源多克隆SNX30抗体，作者发现SNX30在阿尔茨海默病模型中表达显著下调，并通过共聚焦显微镜观察到其与APP蛋白的共定位，提示其可能参与淀粉样蛋白代谢通路。
3. **文献名称**：*"Development and Validation of a Polyclonal Antibody for SNX30 in Lipid Raft Studies"*
**作者**：Garcia, M. et al.
**摘要**：该文献报道了一种高亲和力SNX30多克隆抗体的制备，并通过蛋白质组学分析证实SNX30富集于脂筏微区，可能通过调控膜胆固醇稳态影响细胞迁移。
4. **文献名称**：*"SNX30 Knockout and Antibody-Based Rescue Experiments Highlight Its Immune Regulatory Function"*
**作者**：Wang, Q. et al.
**摘要**：通过CRISPR-Cas9构建SNX30敲除细胞系，结合外源抗体阻断实验，发现SNX30通过调节TLR4内吞途径影响NF-κB信号激活，提示其在先天免疫中的潜在作用。
---
如需真实文献，建议在PubMed或Google Scholar中检索关键词(如"SNX30 antibody" + "sorting nexin")，并筛选涉及抗体开发、验证或功能研究的论文。
SNX30 (Sorting Nexin 30) is a member of the sorting nexin family, a group of proteins involved in membrane trafficking, endosomal sorting, and cellular signaling. These proteins typically contain a Phox homology (PX) domain, which binds phosphoinositides to facilitate membrane association. SNX30 is distinguished by its unique structural features, including a C-terminal region that may mediate protein-protein interactions or regulate subcellular localization. It is implicated in retrograde transport from endosomes to the Golgi apparatus and interacts with components of the retromer complex, which is critical for recycling receptors and cargos. Studies suggest SNX30 may also influence autophagy and lysosomal function, though its precise mechanistic roles remain under investigation.
Antibodies targeting SNX30 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore SNX30's involvement in cellular processes and disease contexts. Dysregulation of sorting nexins has been linked to neurodegenerative disorders, cancer, and metabolic diseases, making SNX30 antibodies valuable for probing its potential contributions to these conditions. Recent research has focused on characterizing SNX30's tissue-specific expression patterns and its interplay with trafficking pathways, highlighting its emerging role in cellular homeostasis and pathology.
×
