Rabbit Polyclonal SOX11 Antibody

The SOX11 antibody is a crucial tool in studying the SOX11 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX11 plays vital roles in embryonic development, tissue homeostasis, and oncogenesis. It regulates cell differentiation, proliferation, and survival, particularly in neural development and organogenesis. Dysregulation of SOX11 is implicated in various cancers, including mantle cell lymphoma (MCL), ovarian carcinoma, and gliomas. In MCL, SOX11 overexpression serves as a diagnostic and prognostic marker, distinguishing it from other B-cell lymphomas. The SOX11 antibody enables detection of this protein in tissues or cells via techniques like immunohistochemistry (IHC), Western blotting, or flow cytometry. Its specificity and sensitivity are critical for accurate research and clinical diagnostics. Researchers also use SOX11 antibodies to explore mechanisms in neurogenesis, tissue regeneration, and cancer metastasis. However, variability in antibody performance across commercial clones necessitates validation for specific applications. Recent studies highlight SOX11's dual role as both tumor suppressor and oncogene, depending on context, driving interest in its therapeutic targeting. Thus, the SOX11 antibody remains essential for advancing molecular pathology, cancer research, and developmental biology.