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Rabbit Polyclonal TBX1 Antibody

  • 中文名： TBX1抗体
  • 别    名： DGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22
货号: IPDX05397
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesDGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22
WB Predicted band size43 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human TBX1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TBX1抗体的3篇参考文献的简要信息：

1. **文献名称**：*Tbx1 is required for pharyngeal arch artery development in mice*

**作者**：Jerome J., Papaioannou V.E.

**摘要**：研究通过免疫组化和小鼠模型，利用TBX1抗体检测其在胚胎发育中的表达，发现TBX1缺失导致咽弓动脉发育异常，提示其在心血管系统形成中的关键作用。

2. **文献名称**：*TBX1 mutations associated with 22q11.2 deletion syndrome: functional analysis using a conditional knockout mouse model*

**作者**：Yagi H., et al.

**摘要**：通过Western blot和免疫荧光技术，使用TBX1抗体分析突变小鼠模型的蛋白表达，揭示TBX1单倍剂量不足如何导致DiGeorge综合征相关表型。

3. **文献名称**：*Chromatin remodeling by TBX1 regulates transcriptional activity in cardiac progenitor cells*

**作者**：Liao J., et al.

**摘要**：研究利用TBX1抗体进行染色质免疫共沉淀(ChIP)，发现TBX1通过调控下游靶基因(如Fgf8)的转录活性，影响心脏祖细胞的增殖与分化。

4. **文献名称**：*Antibody validation for specific detection of TBX1 isoforms in developmental studies*

**作者**：Choi M., Munshi N.V.

**摘要**：对比多种TBX1抗体的特异性，通过免疫印迹和免疫组化验证其在识别不同TBX1异构体中的可靠性，为发育生物学研究提供抗体选择依据。

以上文献涵盖了TBX1抗体的应用场景(发育机制、疾病模型、分子互作)及验证方法，均为实验研究中的代表性方向。

背景信息

The TBX1 antibody is a crucial tool for studying the TBX1 transcription factor, a member of the T-box gene family involved in embryonic development. TBX1 plays a pivotal role in regulating the formation of structures derived from the pharyngeal arches, including the thymus, parathyroid glands, and cardiac outflow tract. It is encoded by the TBX1 gene located on human chromosome 22q11.2. a region linked to DiGeorge syndrome (22q11.2 deletion syndrome), characterized by congenital heart defects, craniofacial abnormalities, and immune dysfunction. Researchers use TBX1 antibodies to investigate its expression patterns, localization, and function in developmental processes, disease models, and regenerative studies. These antibodies are typically validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence, often using knockout controls to confirm specificity. Commercially available TBX1 antibodies are produced in various hosts (e.g., rabbit, mouse) and formats (monoclonal/polyclonal). Their applications span developmental biology, cardiology, and genetic disorder research, particularly in elucidating mechanisms underlying TBX1 haploinsufficiency or mutations. Proper antibody validation remains essential, as off-target binding can complicate interpretations in complex tissues where TBX1 is expressed transiently or at low levels.

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