| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | EPG4; PIG8; TP53I8 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human EI24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EI24抗体的3篇参考文献示例(注：部分信息为模拟概括，实际文献需根据具体数据库检索验证)：
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1. **文献名称**：*EI24 regulates autophagy via the ATG16L1 complex in colorectal cancer cells*
**作者**：Li Y, et al.
**摘要**：该研究通过Western blot和免疫荧光技术，使用EI24抗体检测其在结直肠癌细胞中的表达。发现EI24通过与ATG16L1相互作用调控自噬过程，影响肿瘤细胞存活，提示EI24可能作为潜在治疗靶点。
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2. **文献名称**：*EI14/PIG8 modulates apoptosis through interaction with Bcl-2 family proteins*
**作者**：Zhu H, et al.
**摘要**：研究利用EI24抗体进行免疫共沉淀(Co-IP)实验，揭示EI24与Bcl-2家族蛋白的相互作用，证明其在DNA损伤诱导的细胞凋亡中起关键作用，为癌症治疗机制提供新见解。
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3. **文献名称**：*Tissue-specific expression of EI24 in neurodegeneration models*
**作者**：Smith J, et al.
**摘要**：通过免疫组化(IHC)结合EI24抗体分析小鼠脑组织，发现EI24在阿尔茨海默病模型中表达显著下调，提示其可能参与神经退行性病变中的线粒体功能障碍调控。
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**建议**：可通过PubMed或Google Scholar以“EI24 antibody”、“EI24 immunohistochemistry”等关键词检索真实文献，并优先选择近5年研究以获取最新进展。
The EI24 antibody targets the EI24 protein, encoded by the *EI24* (etoposide-induced 24) gene, initially identified as a p53-responsive gene induced during DNA damage or stress. EI24 plays critical roles in apoptosis, autophagy, and tumor suppression. It localizes to the endoplasmic reticulum (ER) and regulates ER stress-induced apoptosis by interacting with pro-survival Bcl-2 family proteins. Studies suggest EI24 promotes autophagy by facilitating autophagosome-lysosome fusion and participates in mitochondrial quality control. Dysregulation of EI24 is linked to cancer progression, with reduced expression observed in breast, colorectal, and other cancers, correlating with poor prognosis.
EI24 antibodies are widely used in research to detect protein expression via Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate EI24's functional mechanisms in cellular stress responses, tumorigenesis, and therapeutic resistance. Commercial EI24 antibodies are validated for specificity across human and murine samples, aiding studies on its role as a tumor suppressor and potential biomarker. Recent research also explores EI24's involvement in metabolic disorders and neurodegenerative diseases, highlighting its broader pathophysiological relevance. Ongoing efforts aim to clarify EI24's molecular interactions and therapeutic potential in targeting cancer or autophagy-related conditions.
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