| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IL18RAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL18RAP抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *IL-18 Receptor Accessory Protein-Mediated Signal Transduction*
**作者**: Born TL et al.
**摘要内容**: 本研究揭示了IL18RAP在IL-18信号通路中的关键作用，通过抗体阻断实验证实其作为辅助受体与IL-18Rα结合，激活下游NF-κB和MAPK通路，促进炎症反应。
2. **文献名称**: *Genetic and Functional Analysis of IL18RAP in Inflammatory Diseases*
**作者**: Thomassen E et al.
**摘要内容**: 文章通过全基因组关联分析(GWAS)发现IL18RAP基因多态性与类风湿性关节炎和克罗恩病相关，并利用特异性抗体抑制IL18RAP功能，证明其调控Th1细胞分化和炎症因子释放。
3. **文献名称**: *Structural Insights into IL-18 Receptor Complex by Cryo-EM*
**作者**: Zhang Y et al.
**摘要内容**: 利用冷冻电镜技术解析了IL-18与其受体IL-18Rα及辅助蛋白IL18RAP的三元复合物结构，基于抗体标记技术揭示了IL18RAP的构象变化对信号转导的调控机制。
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注：以上文献为示例，实际引用时需核实具体期刊及作者信息。如需更多文献，可进一步限定研究领域(如肿瘤、自身免疫病等)。
The IL18RAP (Interleukin-18 Receptor Accessory Protein) antibody targets a key component of the interleukin-18 (IL-18) signaling pathway. IL18RAP is a transmembrane protein that forms a heterodimeric receptor complex with IL-18Rα (IL1RL1) to mediate IL-18 signaling. This cytokine receptor plays a critical role in regulating innate and adaptive immune responses, particularly in promoting Th1 cell differentiation, enhancing NK cell activity, and driving inflammatory cascades. IL-18 itself is implicated in autoimmune diseases, chronic inflammation, and cancer.
Antibodies against IL18RAP are primarily used in research to study the receptor's expression, function, and interaction with IL-18. They enable detection of IL18RAP in immune cells via techniques like flow cytometry, immunohistochemistry, or Western blotting. Dysregulated IL-18 signaling, linked to altered IL18RAP expression, has been observed in conditions such as rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Therapeutic strategies targeting IL-18/IL18RAP signaling, including neutralizing antibodies, are under investigation to modulate excessive inflammation. Recent studies also explore IL18RAP as a potential biomarker for disease severity or treatment response. However, the therapeutic application of IL18RAP antibodies remains experimental, requiring further validation of their efficacy and safety in clinical settings.
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