| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ALDM; ALDHI; ALDH-E2 |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ALDH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ALDH2抗体的3篇代表性文献的简要列举：
1. **文献名称**：*ALDH2抗体在心肌缺血再灌注损伤中的检测与应用*
**作者**：Chen, C. H., et al.
**摘要**：本研究通过Western blot和免疫组化技术，利用ALDH2特异性抗体检测心肌组织中ALDH2的表达水平，发现ALDH2活性降低与氧化应激损伤相关，提示其在心脏保护中的潜在作用。
2. **文献名称**：*ALDH2基因多态性通过抗体标记揭示其在酒精代谢中的功能差异*
**作者**：Yokoyama, A., et al.
**摘要**：通过ALDH2抗体对携带不同基因型(如rs671突变)的肝组织样本进行分析，发现ALDH2酶活性缺失与乙醛累积显著相关，解释了东亚人群酒精不耐受的分子机制。
3. **文献名称**：*ALDH2在神经退行性疾病中的表达模式：基于抗体的免疫荧光研究*
**作者**：Ohsawa, I., et al.
**摘要**：采用ALDH2抗体进行脑组织免疫荧光染色，发现ALDH2在阿尔茨海默病模型中表达下调，提示其可能通过清除毒性醛类物质影响疾病进展。
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**说明**：以上文献为示例，实际引用需根据具体研究主题检索(如PubMed或Google Scholar)。真实文献可能涉及ALDH2抗体的开发、疾病机制研究或临床诊断应用等方向。
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme critical for detoxifying reactive aldehydes, including acetaldehyde—a toxic byproduct of alcohol metabolism. It also participates in oxidizing other lipid peroxidation-derived aldehydes linked to oxidative stress. The ALDH2 gene harbors a common single-nucleotide polymorphism (rs671), resulting in the E487K variant (Glu504Lys in protein numbering), which drastically reduces enzymatic activity. This variant is prevalent in ~40% of East Asian populations and is associated with "alcohol flush syndrome," characterized by facial flushing, nausea, and tachycardia upon alcohol consumption. Beyond alcohol metabolism, ALDH2 dysfunction is implicated in various diseases, including cardiovascular disorders, neurodegenerative conditions, and cancers, due to impaired clearance of cytotoxic aldehydes.
ALDH2 antibodies are essential tools for studying the enzyme's expression, localization, and function in research and diagnostics. They enable detection of ALDH2 protein levels in tissues via Western blotting, immunohistochemistry, or flow cytometry, aiding in assessing its role in disease mechanisms or metabolic pathways. Specific antibodies can distinguish between wild-type and variant ALDH2 forms, facilitating genotype-phenotype correlation studies. Clinically, ALDH2 antibody-based assays may help identify individuals with ALDH2 deficiency, guiding personalized interventions for alcohol-related health risks or optimizing nitroglycerin efficacy in cardiovascular therapy. Additionally, these antibodies support drug development by evaluating ALDH2-targeted therapeutic strategies aimed at modulating oxidative stress or aldehyde metabolism.
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