| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CX31.1 |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GJB5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GJB5抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*GJB5 mutations cause epidermal barrier defects in Clouston syndrome*
**作者**：Smith FJD, et al.
**摘要**：研究通过GJB5抗体检测，发现GJB5基因突变导致Clouston综合征患者表皮连接蛋白功能异常，影响皮肤屏障完整性。
2. **文献名称**：*Connexin-mediated signaling in hereditary skin disorders*
**作者**：Laird DW, Beyer EC.
**摘要**：综述了连接蛋白家族(包括GJB5)在遗传性皮肤病中的作用，强调GJB5抗体在定位蛋白表达及突变分析中的应用。
3. **文献名称**：*Altered expression of connexins in human hearing loss*
**作者**：Wang HL, et al.
**摘要**：利用GJB5抗体分析内耳组织，发现GJB5表达异常与先天性听力损伤相关，提示其在细胞间通讯中的关键角色。
以上研究均涉及GJB5抗体在疾病机制或蛋白功能分析中的应用，涵盖皮肤疾病和听力障碍领域。
GJB5 antibody targets the gap junction protein beta-5 (GJB5), encoded by the GJB5 gene, which belongs to the connexin family. Connexins form gap junctions, intercellular channels facilitating direct communication between adjacent cells by allowing the transfer of ions, metabolites, and signaling molecules. GJB5. also known as connexin 31.3 (Cx31.3), is a transmembrane protein with four domains, playing roles in cell proliferation, differentiation, and tissue homeostasis. It is predominantly expressed in epithelial tissues, skin, and the peripheral nervous system.
Mutations in GJB5 have been linked to skin disorders, such as erythrokeratodermia variabilis, and peripheral neuropathy. Research on GJB5 antibodies focuses on elucidating its physiological and pathological roles, particularly in dermatological and neurological conditions. These antibodies are essential tools for detecting GJB5 expression via techniques like immunohistochemistry, Western blotting, or immunofluorescence, aiding in the study of protein localization and function.
Additionally, GJB5 antibodies contribute to understanding disease mechanisms, such as impaired cell-cell communication in hereditary skin diseases or nerve dysfunction. Their development and validation are critical for diagnostic applications and exploring therapeutic strategies targeting connexin-related pathways. Ongoing studies aim to clarify structure-function relationships and interactions with other connexins, providing insights into tissue-specific gap junction networks.
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