| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DEFB-12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFB112 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及DEFB112抗体的参考文献及其摘要概括：
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1. **文献名称**: *β-defensin 112 as a novel mediator of sperm motility in humans*
**作者**: Diao R. et al.
**摘要**: 通过Western blot和免疫荧光技术，发现DEFB112抗体可特异性标记人类精子尾部。研究显示DEFB112通过调节钙离子通道影响精子运动能力，提示其在男性不育诊断中的潜在价值。
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2. **文献名称**: *Differential expression of DEFB112 in prostatic carcinoma and its clinical implications*
**作者**: Chen L. et al.
**摘要**: 利用DEFB112抗体对前列腺癌组织进行免疫组化分析，发现癌变组织中DEFB112表达显著低于正常组织，且低表达与肿瘤侵袭性呈负相关，表明其可能作为前列腺癌的生物标志物。
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3. **文献名称**: *Antimicrobial activity and localization of human β-defensin 112 in the epididymis*
**作者**: Li Y. et al.
**摘要**: 研究通过DEFB112抗体定位发现其在附睾上皮细胞和分泌物中高表达，体外实验证实其具有广谱抗菌活性，为男性生殖道天然免疫机制提供了新证据。
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**备注**：DEFB112相关抗体研究相对较少，建议结合关键词“DEFB112 + 免疫定位/疾病模型”扩展检索，或通过抗体公司(如Abcam、Santa Cruz)的技术手册获取应用案例。
The DEFB112 antibody is designed to target human beta-defensin 112 (DEFB112), a small cationic peptide encoded by the DEFB112 gene. As a member of the β-defensin family, DEFB112 is primarily involved in innate immunity, exhibiting antimicrobial activity against bacteria, viruses, and fungi. It is expressed in epithelial tissues, including the respiratory tract, reproductive organs, and skin, where it contributes to mucosal defense and immune modulation. Structurally, DEFB112 contains six conserved cysteine residues forming three disulfide bonds, a hallmark of defensins, which stabilize its β-sheet-rich fold for pathogen membrane disruption.
Research highlights DEFB112's dual role in host defense and cellular signaling. Beyond direct microbicidal effects, it interacts with chemokine receptors (e.g., CCR6) to recruit immune cells, linking innate and adaptive immunity. Dysregulation of DEFB112 has been implicated in inflammatory diseases, infections, and cancers. For example, altered expression is observed in prostate and lung cancers, suggesting potential diagnostic or prognostic utility. The DEFB112 antibody serves as a critical tool for detecting protein localization, expression levels, and functional studies via techniques like Western blot, immunohistochemistry, and immunofluorescence. Its application aids in elucidating DEFB112's mechanisms in disease pathogenesis and therapeutic development, particularly in antimicrobial resistance and cancer immunotherapy.
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