| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IBP2; IGF-BP53 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human IGFBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGFBP2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"IGFBP2 is a biomarker for predicting malignant glioma outcomes and a mediator of tumor cell invasion"*
**作者**：Wang H, et al.
**摘要**：该研究利用IGFBP2抗体通过免疫组化(IHC)和Western blot分析胶质母细胞瘤样本，发现IGFBP2高表达与患者预后不良相关，并证实其通过调控细胞迁移和侵袭促进肿瘤进展。
2. **文献名称**：*"Insulin-like growth factor-binding protein 2 (IGFBP2) as a serum biomarker in epithelial ovarian cancer"*
**作者**：Rocha RL, et al.
**摘要**：研究采用ELISA和IGFBP2特异性抗体检测卵巢癌患者血清，发现IGFBP2水平显著升高，可作为潜在的诊断标志物，并与肿瘤分期和转移相关。
3. **文献名称**：*"Targeting IGFBP2 in metabolic diseases: Insights from adipose tissue regulation"*
**作者**：Booth A, et al.
**摘要**：通过免疫沉淀和Western blot分析，研究发现IGFBP2抗体可阻断脂肪细胞中IGFBP2与胰岛素样生长因子的相互作用，揭示其在肥胖和胰岛素抵抗中的调控作用，提示其作为代谢疾病治疗靶点的潜力。
(注：以上文献信息为示例，实际引用时需核对具体来源及准确性。)
The insulin-like growth factor-binding protein 2 (IGFBP2) antibody is a crucial tool for studying the role of IGFBP2. a member of the IGFBP family that modulates the bioavailability and activity of insulin-like growth factors (IGFs). IGFBP2 binds IGF-1 and IGF-2. regulating their interaction with cell surface receptors, thereby influencing cell proliferation, differentiation, and metabolism. Dysregulation of IGFBP2 is implicated in various pathologies, including cancer, metabolic disorders, and neurodegenerative diseases. Elevated IGFBP2 levels are frequently observed in malignancies like glioblastoma, breast, and colorectal cancers, where it promotes tumor progression via IGF-dependent and IGF-independent pathways, such as integrin signaling.
IGFBP2 antibodies are widely used in research to detect and quantify IGFBP2 expression in tissues and biofluids (e.g., serum, cerebrospinal fluid) using techniques like Western blotting, immunohistochemistry (IHC), and ELISA. These antibodies aid in elucidating IGFBP2's role in disease mechanisms, prognostic biomarker potential, and therapeutic targeting. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing detection sensitivity. Validation via knockout controls or immunoprecipitation is critical to ensure antibody reliability. Additionally, IGFBP2 antibodies are employed in functional studies to block or neutralize IGFBP2 activity, helping dissect its molecular interactions. Their application spans cancer biology, neurology, and endocrinology, underscoring IGFBP2's multifaceted roles in health and disease.
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