| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MT2; FGQTL2; MEL-1B-R |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MTNR1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MTNR1B抗体的模拟参考文献示例(注：文献为虚构，仅供参考格式及内容方向)：
1. **"Development of a Polyclonal Antibody for Human MTNR1B and Its Application in Pancreatic β-Cell Studies"**
- **作者**: Smith A, et al.
- **摘要**: 本研究开发了一种针对人MTNR1B受体C末端结构域的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。该抗体成功用于检测胰岛β细胞中MTNR1B的蛋白表达，揭示了其与胰岛素分泌调控的关联。
2. **"MTNR1B Receptor Localization in Mammalian Retina Using a Novel Monoclonal Antibody"**
- **作者**: Lee C, et al.
- **摘要**: 通过杂交瘤技术制备了高特异性抗MTNR1B单克隆抗体，并应用于视网膜组织的免疫组化分析。研究发现MTNR1B在视网膜感光细胞中高表达，提示其可能在昼夜节律的光信号传递中发挥作用。
3. **"Antibody-Based Profiling of MTNR1B Expression in Type 2 Diabetes Patients"**
- **作者**: García-Ruiz E, et al.
- **摘要**: 利用商业化MTNR1B抗体对2型糖尿病患者肝脏和脂肪组织进行蛋白表达分析，发现MTNR1B表达水平与空腹血糖和胰岛素抵抗呈显著负相关，支持其在糖代谢中的功能。
**提示**：实际研究中请通过PubMed、Google Scholar等平台检索真实文献，关键词可包括“MTNR1B antibody”、“melatonin receptor 1B antibody application”等。
The MTNR1B (melatonin receptor 1B) gene encodes a G protein-coupled receptor that binds melatonin, a hormone regulating circadian rhythms and metabolic processes. Primarily expressed in pancreatic islets, retina, and brain, MTNR1B mediates melatonin's effects on glucose homeostasis and insulin secretion. Genetic variations in MTNR1B, particularly the rs10830963 SNP, are strongly associated with type 2 diabetes and impaired fasting glucose, likely through altered receptor expression or signaling that disrupts β-cell function.
MTNR1B antibodies are essential tools for studying receptor localization, expression patterns, and molecular mechanisms in metabolic diseases. Researchers use these antibodies in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate MTNR1B's role in melatonin signaling pathways involving cAMP inhibition and kinase activation. Recent studies focus on its dual impact on circadian regulation and metabolic disorders, exploring therapeutic potential in diabetes management and sleep-related metabolic syndromes. Commercial MTNR1B antibodies are typically validated for specificity against human/mouse isoforms, enabling cross-species comparative studies. Challenges remain in clarifying its tissue-specific signaling cascades and developing targeted modulators for clinical applications.
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