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Rabbit Polyclonal BCL2L10 Antibody

  • 中文名: BCL2L10抗体
  • 别    名: Boo; Diva; BCL-B; bcl2-L-10
货号: IPDX06055
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBoo; Diva; BCL-B; bcl2-L-10
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human BCL2L10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于BCL2L10抗体的参考文献(摘要内容为简化概括):

1. **文献名称**: "BCL2L10/Boo is a novel regulator of apoptosis in breast cancer cells"

**作者**: Lee EF, et al.

**摘要**: 研究利用特异性BCL2L10抗体揭示其在乳腺癌细胞中通过调控线粒体膜电位抑制凋亡的机制,并发现其高表达与化疗耐药相关。

2. **文献名称**: "Development of a monoclonal antibody against BCL2L10 for immunohistochemical analysis in ovarian cancer"

**作者**: Zhang Y, et al.

**摘要**: 报道了一种新型BCL2L10单克隆抗体的开发,验证其在卵巢癌组织中的特异性表达,发现其表达水平与患者预后显著相关。

3. **文献名称**: "BCL2L10 interacts with pro-apoptotic proteins to modulate TRAIL-induced apoptosis in colorectal carcinoma"

**作者**: Chen L, et al.

**摘要**: 通过BCL2L10抗体进行免疫共沉淀实验,证明其与Bax/Bak蛋白互作,抑制TRAIL通路诱导的结直肠癌细胞凋亡,提示其作为治疗靶点的潜力。

*注:以上文献为虚拟示例,实际引用需查询PubMed等数据库获取真实研究。*

背景信息

The BCL2L10 antibody targets the BCL2-like 10 protein (BCL2L10), a member of the BCL-2 protein family that regulates apoptosis by modulating mitochondrial membrane permeability. BCL2L10. also known as BCL-B or Diva, functions as an anti-apoptotic protein, interacting with pro-apoptotic BCL-2 family members like BAX and BAK to inhibit cytochrome c release and caspase activation. Its expression is tissue-specific and has been implicated in various cancers, including ovarian, breast, and hepatocellular carcinomas, where overexpression is associated with chemoresistance and poor prognosis. Antibodies against BCL2L10 are critical tools for studying its expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore its role in apoptosis regulation and cancer progression. Additionally, these antibodies support therapeutic research, as targeting BCL2L10 may enhance chemosensitivity in resistant tumors. Validation of antibody specificity remains essential due to sequence homology within the BCL-2 family. Research on BCL2L10 continues to uncover its dual roles in apoptosis and unexpected functions in cellular processes like autophagy and metabolism.

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