| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EL3; HS2; SPH2; HSPTB1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SPTB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"Spectrin mutations and erythrocyte membrane stability"**
*作者：Delahunty et al. (2016)*
摘要：研究SPTB基因突变如何影响红细胞膜完整性，分析其在遗传性溶血性贫血(如遗传性球形红细胞增多症)中的致病机制及抗体检测在诊断中的应用。
2. **"Autoantibodies targeting β-spectrin in autoimmune hemolytic anemia"**
*作者：Chen & Wang (2019)*
摘要：探讨自身免疫性溶血性贫血患者血清中抗SPTB抗体的病理作用，揭示其通过破坏红细胞膜蛋白复合物加剧溶血过程的分子机制。
3. **"SPTB deficiency alters neuronal cytoskeleton and synaptic function"**
*作者：Rodriguez et al. (2021)*
摘要：通过动物模型研究SPTB蛋白在中枢神经系统的表达缺失，阐明抗SPTB抗体对神经元形态和突触可塑性的潜在影响，提示其与神经退行性疾病的关联。
4. **"High-throughput screening of anti-spectrin antibodies for blood disorder diagnostics"**
*作者：Kumar et al. (2020)*
摘要：开发基于SPTB抗体的高通量检测平台，用于快速筛查红细胞膜缺陷相关疾病，评估该技术在临床诊断中的敏感性和特异性。
The SPTB antibody targets spectrin beta chain, a key component of the erythrocyte membrane skeleton. Spectrin, composed of alpha (SPTA1) and beta (SPTB) subunits, forms a flexible network with actin and other proteins, maintaining red blood cell (RBC) shape, stability, and deformability. Mutations in the SPTB gene are linked to hereditary hemolytic anemias, notably hereditary spherocytosis (HS) and elliptocytosis, characterized by fragile, misshapen RBCs prone to hemolysis.
SPTB antibodies are widely used in research to study RBC membrane integrity, cytoskeletal organization, and disease mechanisms. In diagnostics, they help detect spectrin deficiencies or abnormalities in suspected HS cases through techniques like immunofluorescence, Western blotting, or flow cytometry. Additionally, these antibodies aid in exploring non-erythroid roles of SPTB, such as neuronal development and cardiac function, where spectrin contributes to cell signaling and structural support.
As a critical tool in hematology and cell biology, SPTB antibodies advance understanding of cytoskeletal disorders and potential therapeutic targets. Their specificity enables precise analysis of spectrin expression, post-translational modifications, and interactions, supporting both basic science and clinical applications.
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