| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C13orf34 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BORA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BORA抗体的3篇模拟参考文献示例，涵盖其功能研究及实验应用：
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1. **文献名称**：*"Bora phosphorylation orchestrates the G2/M transition by activating Plk1 in human cells"*
**作者**：Seki, A., Coppinger, J.A., Jang, C.Y., et al.
**摘要**：该研究通过特异性BORA抗体进行免疫沉淀和蛋白质印迹分析，揭示了BORA在有丝分裂启动中的关键作用。研究表明，BORA通过磷酸化激活PLK1激酶，调控细胞周期G2/M期转换，抗体应用为验证BORA与PLK1的相互作用提供了关键实验支持。
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2. **文献名称**：*"Characterization of Bora antibodies for functional studies in DNA damage response"*
**作者**：Di Fiore, B., Davey, N.E., Hagting, A., et al.
**摘要**：本文系统评估了多种BORA抗体的特异性和适用性，发现部分抗体适用于免疫荧光染色和染色质共沉淀(ChIP)。研究利用这些抗体证实，BORA在DNA损伤应答中通过招募ATR激酶至损伤位点，维持基因组稳定性。
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3. **文献名称**：*"Development of a monoclonal BORA antibody for clinical tumor profiling"*
**作者**：Pahlavan, G., Rosenblatt, M., Wu, S., et al.
**摘要**：研究团队开发了一种高灵敏度的单克隆BORA抗体，并应用于乳腺癌组织样本的免疫组化分析。结果显示，BORA高表达与患者不良预后相关，提示其作为潜在肿瘤标志物的临床价值。
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**备注**：以上文献为模拟示例，实际引用时需以真实发表的论文为准。建议通过PubMed或Google Scholar检索关键词“BORA antibody”、“BORA PLK1”等获取最新研究。
BORA (BORA Aurora Kinase A Activator) is a key regulatory protein involved in cell cycle progression, particularly during the G2/M phase transition and mitotic entry. Initially identified in *Drosophila* as a partner of Aurora A kinase, BORA facilitates the activation of Aurora A by recruiting and stabilizing it at centrosomes and mitotic spindles. This interaction is critical for proper centrosome maturation, spindle assembly, and timely mitotic progression. BORA also cooperates with Plk1 (Polo-like kinase 1) to regulate the phosphorylation cascade essential for mitotic initiation.
Antibodies targeting BORA are vital tools for studying its expression, localization, and functional dynamics in cell cycle regulation. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate BORA’s role in healthy and pathological contexts, such as cancer. Dysregulation of BORA has been linked to chromosomal instability and tumorigenesis, making it a potential biomarker or therapeutic target. These antibodies help elucidate molecular mechanisms underlying cell division errors and oncogenic pathways, offering insights into disease diagnostics and treatment strategies. Research utilizing BORA antibodies continues to expand our understanding of mitotic regulation and its implications in cellular health and disease.
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