| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CELF-5; BRUNOL5; BRUNOL-5 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CELF5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CELF5抗体的3篇参考文献示例(注：文献为虚构示例，实际引用需核实真实来源)：
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1. **文献名称**：*CELF5-Mediated Alternative Splicing in Neuronal Development*
**作者**：A. Smith et al.
**摘要**：通过CELF5抗体进行免疫共沉淀和Western blot分析，揭示了CELF5在调控神经元mRNA剪接中的关键作用，其异常表达与自闭症谱系障碍的病理机制相关。
2. **文献名称**：*CELF5 Expression Dynamics in Amyotrophic Lateral Sclerosis*
**作者**：B. Johnson & R. Lee
**摘要**：利用CELF5抗体对患者肌肉组织进行免疫组化检测，发现CELF5蛋白水平在肌萎缩侧索硬化症(ALS)中显著升高，提示其可能参与运动神经元退化的调控通路。
3. **文献名称**：*CELF5 Antibody Validation for Tumor Biomarker Studies*
**作者**：C. Zhang et al.
**摘要**：研究开发了一种高特异性CELF5抗体，并通过免疫荧光验证其在胶质母细胞瘤中的表达定位，证明CELF5可作为潜在肿瘤分级的分子标志物。
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**注意**：以上文献信息为示例性质，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的论文，并关注抗体应用的具体实验场景(如物种特异性、亚细胞定位等)。
The CELF5 antibody targets the CELF5 protein, a member of the CUGBP Elav-like family (CELF) of RNA-binding proteins. CELF proteins regulate RNA metabolism, including splicing, stability, translation, and localization. CELF5. encoded by the *CELF5* gene in humans (chromosome 15q25.3), contains conserved RNA recognition motifs (RRMs) critical for binding mRNA and modulating post-transcriptional processes. It is highly expressed in the brain, muscle, and testes, suggesting roles in neuronal function, neuromuscular signaling, and spermatogenesis.
Research highlights CELF5's involvement in neurodevelopment and disease. It regulates alternative splicing of synaptic proteins and ion channels, impacting neuronal excitability and synaptic plasticity. Dysregulation of CELF5 has been linked to neurological disorders, including autism spectrum disorder (ASD), intellectual disability, and amyotrophic lateral sclerosis (ALS). In ALS, aberrant CELF5 activity may disrupt RNA processing in motor neurons, contributing to neurodegeneration. Additionally, CELF5 is implicated in cancer, where altered expression correlates with tumor progression and metastasis in certain malignancies.
CELF5 antibodies are essential tools for detecting protein expression, localization, and interactions in experimental models (e.g., Western blot, immunohistochemistry). They enable studies on CELF5's role in RNA-binding dynamics, disease mechanisms, and potential therapeutic targets. However, antibody specificity and validation remain critical due to homology among CELF family members. Understanding CELF5's molecular functions and pathological relevance continues to advance insights into RNA-mediated diseases and precision medicine approaches.
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