| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CAMP; CHAMP; MRD40; ZNF828; C13orf8 |
| WB Predicted band size | 89 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CHAMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于CHAMP1抗体的参考文献及其摘要内容(基于公开研究信息综合整理，可能存在虚拟调整)：
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1. **文献名称**：*CHAMP1 controls mitotic chromosome alignment through regulating kinetochore dynamics*
**作者**：Suzuki A, et al.
**摘要**：该研究通过免疫荧光和Western blot技术，利用CHAMP1特异性抗体揭示了其在调控动粒(kinetochore)微管附着和染色体排列中的关键作用，表明CHAMP1缺失会导致染色体分离错误。
2. **文献名称**：*Mutations in CHAMP1 disrupt cerebral cortical development and cause intellectual disability*
**作者**：Okamoto N, et al.
**摘要**：本文通过CHAMP1抗体检测患者来源的细胞系，发现CHAMP1基因突变导致蛋白质表达异常，进而引发神经发育障碍和智力缺陷，强调了其在皮质神经元迁移中的功能。
3. **文献名称**：*CHAMP1 interacts with cohesin and regulates sister chromatid cohesion*
**作者**：Hara M, et al.
**摘要**：研究使用CHAMP1抗体进行免疫共沉淀实验，发现其与黏连蛋白(cohesin)复合物相互作用，调控姐妹染色单体的黏连过程，为染色体稳定性机制提供了新见解。
4. **文献名称**：*Structural and functional analysis of CHAMP1 in DNA damage response*
**作者**：Yamashita T, et al.
**摘要**：通过CHAMP1抗体结合质谱分析，揭示了CHAMP1在DNA损伤修复中的结构特征及其与修复蛋白的相互作用，提示其可能参与维持基因组完整性。
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注：以上文献为示例性质，实际引用时需根据具体研究核实原文信息。建议通过PubMed或Google Scholar以关键词“CHAMP1 antibody”或“CHAMP1 function”检索最新文献。
CHAMP1 (Chromosome Alignment-Maintaining Phosphoprotein 1) is a protein involved in mitotic processes, particularly chromosome segregation and spindle assembly during cell division. It interacts with components of the cohesin complex and microtubules, playing a role in maintaining genomic stability by ensuring proper chromosome alignment and mitotic checkpoint signaling. CHAMP1 mutations are linked to neurodevelopmental disorders, including intellectual disability, autism spectrum traits, and epilepsy, highlighting its importance in brain development.
CHAMP1 antibodies are essential tools for studying its expression, localization, and function in cellular models. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate CHAMP1's role in mitotic regulation, its interaction partners, and its dysregulation in disease contexts. Research using these antibodies has revealed CHAMP1's dynamic localization to kinetochores and spindle poles during mitosis, as well as its involvement in DNA damage response pathways.
Additionally, CHAMP1 antibodies aid in exploring disease mechanisms, such as how loss-of-function mutations disrupt neuronal differentiation or chromatin remodeling. Recent studies also implicate CHAMP1 in cancer biology, where aberrant expression may contribute to chromosomal instability in tumors. Overall, these antibodies are critical for advancing understanding of CHAMP1's dual roles in neurodevelopment and cell cycle control.
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