| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VF2; DPL1; DPPX; MRD33 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DPP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DPP6抗体的3篇代表性文献示例(注：部分内容为模拟概括，仅供参考)：
1. **文献名称**：*Autoantibodies to DPP6 in autoimmune encephalitis: clinical and functional characterization*
**作者**：Bien CG, et al.
**摘要**：该研究首次报道了在自身免疫性脑炎患者血清中发现DPP6抗体。通过免疫组织化学和细胞转染实验，证实抗体特异性靶向DPP6蛋白，并与患者认知障碍、癫痫发作相关。研究表明DPP6抗体可能通过干扰钾通道复合体功能导致神经元兴奋性异常。
2. **文献名称**：*DPP6 modulates Kv4.2 channel trafficking and gating in cerebellar neurons*
**作者**：Misonou H, et al.
**摘要**：研究利用DPP6特异性抗体进行共聚焦成像和免疫共沉淀实验，揭示DPP6在小脑浦肯野细胞中与Kv4.2钾通道的共定位及相互作用，证明其通过调节通道动力学影响动作电位复极化过程。
3. **文献名称**：*Novel autoantibody targets in neuropsychiatric syndromes: DPP6 as a potential biomarker*
**作者**：van Elk J, et al.
**摘要**：通过大规模筛查发现，部分精神分裂症和情感障碍患者血清中存在DPP6抗体。实验显示这些抗体可结合海马神经元DPP6蛋白，提示其可能通过破坏神经元网络稳定性参与精神疾病病理机制。
**注意**：以上文献信息为示例性概括，具体研究请以实际发表的论文为准。建议通过PubMed或Google Scholar以“DPP6 antibody”或“DPP6 autoantibody”为关键词检索最新文献。
The DPP6 (dipeptidyl peptidase-like protein 6) antibody targets a protein belonging to the dipeptidyl peptidase IV family, though it lacks enzymatic activity. DPP6. also known as DPPX, is a type II transmembrane glycoprotein that modulates voltage-gated potassium channels (Kv4 family), influencing neuronal and cardiac excitability. It is highly expressed in the brain, pancreas, and heart. Research on DPP6 antibodies primarily focuses on understanding its role in regulating ion channel function, synaptic plasticity, and neural network dynamics.
DPP6 has been implicated in neurodevelopmental and neurodegenerative disorders. Studies link DPP6 gene variations to susceptibility to Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Additionally, altered DPP6 expression is observed in certain cancers, suggesting potential as a biomarker. Autoantibodies against DPP6 are rare but associated with autoimmune encephalitis, highlighting its relevance in neuroimmunology.
Antibodies targeting DPP6 are critical tools for immunohistochemistry, Western blotting, and functional studies to map protein distribution, quantify expression levels, and dissect molecular interactions. Their development aids in exploring DPP6’s contribution to disease mechanisms and therapeutic targeting. Ongoing research aims to clarify its dual roles in physiology and pathology, bridging gaps between ion channel biology and complex neurological conditions.
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