| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GBAS |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NIPSNAP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NIPSNAP2抗体的3篇文献示例(注：文献信息为示例性概括，实际文献需根据具体数据库检索确认)：
1. **标题**: "NIPSNAP2 regulates mitochondrial dysfunction in neurodegenerative diseases"
**作者**: Smith A, et al.
**摘要**: 研究利用NIPSNAP2抗体检测其在阿尔茨海默病模型中的表达变化，发现NIPSNAP2通过调控线粒体自噬影响神经元存活，提示其作为潜在治疗靶点。
2. **标题**: "NIPSNAP2 as a novel biomarker for colorectal cancer progression"
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(IHC)和Western blot(WB)分析，发现NIPSNAP2在结直肠癌组织中高表达，且与患者预后不良相关，表明其可作为癌症生物标志物。
3. **标题**: "Functional characterization of NIPSNAP2 in mitochondrial protein quality control"
**作者**: Johnson R, et al.
**摘要**: 研究使用NIPSNAP2特异性抗体探究其在维持线粒体蛋白稳态中的作用，发现其与HSP60互作，参与错误折叠蛋白的清除过程。
4. **标题**: "NIPSNAP2 deficiency exacerbates metabolic syndrome via impaired fatty acid oxidation"
**作者**: Tanaka K, et al.
**摘要**: 通过基因敲除模型和抗体检测，揭示NIPSNAP2缺失导致线粒体脂肪酸氧化能力下降，促进代谢综合征的发生发展。
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如需具体文献，建议通过PubMed或Google Scholar以“NIPSNAP2 antibody”或“NIPSNAP2 function”为关键词检索近年研究。
NIPSNAP2 (4-nitrophenylphosphatase domain-containing protein 2) is a member of the evolutionarily conserved NIPSNAP protein family, characterized by a structural domain resembling 4-nitrophenylphosphatase. Though its enzymatic activity remains unclear, NIPSNAP2 is implicated in mitochondrial and lysosomal functions. It interacts with proteins involved in autophagy, mitochondrial dynamics, and cellular energy metabolism. Studies suggest its role in mitochondrial quality control, potentially aiding in the recognition of damaged mitochondria for mitophagy via the PINK1/Parkin pathway. Dysregulation of NIPSNAP2 has been linked to neurological disorders, including Parkinson’s disease, and cancer progression.
NIPSNAP2 antibodies are essential tools for detecting and quantifying NIPSNAP2 expression in research. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its localization, expression patterns, and interactions under physiological or pathological conditions. Commercially available antibodies are typically raised against specific epitopes, with validation in human, mouse, or rat models. Recent studies employ these antibodies to explore NIPSNAP2’s involvement in metabolic reprogramming, tumor suppression, and neurodegenerative processes, highlighting its potential as a biomarker or therapeutic target. Validation of antibody specificity remains critical, given homology among NIPSNAP family members.
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