Rabbit Polyclonal MOB3B Antibody

The MOB3B antibody targets MOB kinase activator 3B (MOB3B), a member of the MOB (Mps One Binder) protein family, which plays regulatory roles in cell cycle progression, apoptosis, and signal transduction pathways. MOB proteins, including MOB1. MOB2. and MOB3 isoforms, are evolutionarily conserved and interact with kinases such as LATS1/2 in the Hippo pathway to control organ size and tissue homeostasis. MOB3B shares structural homology with MOB1 but exhibits distinct functional properties, though its precise biological mechanisms remain less characterized compared to other MOB family members. Research suggests MOB3B may influence centrosome dynamics and mitotic progression, though its exact role in Hippo signaling or other pathways is still under investigation. The MOB3B antibody is primarily used in studies to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its applications span cancer biology (due to Hippo pathway dysregulation in tumors), developmental biology, and cell cycle regulation research. Validated antibodies help clarify MOB3B's tissue-specific expression patterns and potential contributions to diseases, offering insights into its regulatory crosstalk with other signaling networks. Further studies are needed to fully elucidate its physiological and pathological relevance.