| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TED; TMEM28; CXorf63; bB57D9.1 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FAM155B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FAM155B抗体的虚构参考文献示例(注：因该基因研究较少，实际文献可能有限，以下内容仅作格式参考)：
1. **"Characterization of FAM155B-Specific Antibody for Neuronal Localization Studies"**
*作者：Zhang L. et al.*
*摘要：* 本研究开发并验证了一种针对FAM155B蛋白的多克隆抗体，通过免疫印迹和免疫荧光证实其特异性，发现FAM155B在小鼠脑组织中高表达，且主要定位于神经元胞体，提示其在神经功能中的潜在作用。
2. **"FAM155B Antibody Reveals Interaction with Potassium Channel Subunits"**
*作者：Tanaka K. et al.*
*摘要：* 利用FAM155B抗体进行免疫共沉淀实验，首次证明FAM155B与电压门控钾离子通道蛋白Kv2.1存在物理相互作用，提示其可能参与调节神经元兴奋性及动作电位发放。
3. **"Dysregulation of FAM155B in Autism Spectrum Disorder: Evidence from Antibody-Based Proteomic Analysis"**
*作者：Gupta R. et al.*
*摘要：* 通过抗体介导的蛋白质组学检测，发现自闭症患者前额叶皮层中FAM155B表达显著下调，其表达水平与突触相关蛋白呈正相关，表明其可能在神经发育障碍中发挥作用。
The FAM155B antibody is a research tool designed to detect and study the FAM155B protein, a member of the FAM155 (Family with sequence similarity 155) family. FAM155B, also known as TMEM86B, is a transmembrane protein encoded by the FAM155B gene located on human chromosome 12. While its precise biological function remains under investigation, FAM155B has been implicated in regulating neuronal excitability and calcium signaling through its interaction with voltage-gated calcium channels, particularly Cav3 T-type channels. Studies suggest it may modulate channel gating or trafficking, influencing cellular processes like neurotransmitter release and action potential firing.
FAM155B antibodies are typically developed for applications such as Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions in tissues or cultured cells. Research has explored its potential roles in neurological disorders, including epilepsy and neuropathic pain, where calcium channel dysregulation is implicated. Recent work also links FAM155B to cancer progression, with altered expression observed in certain malignancies.
Despite its emerging significance, FAM155B's molecular mechanisms and physiological relevance require further elucidation. Antibody validation remains critical due to sequence similarities with paralogs like FAM155A. Ongoing studies aim to clarify its structure-function relationships and therapeutic potential in channelopathies or other diseases.
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