| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FAE; FACE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FANCE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于FANCE抗体的代表性文献的简要信息：
---
1. **文献名称**: *"A physical interaction between human FANCE and FANCD2 is essential for the Fanconi anemia pathway"*
**作者**: Meetel, A.R. et al.
**摘要**: 该研究通过特异性抗体验证FANCE蛋白与FANCD2的直接相互作用，证明其在FA通路DNA损伤修复中的关键作用，并利用抗体进行免疫共沉淀实验分析复合物形成机制。
---
2. **文献名称**: *"Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in the Fanconi anemia pathway"*
**作者**: Garcia-Higuera, I. et al.
**摘要**: 研究利用FANCE抗体检测FANCD2的单泛素化修饰，揭示FANCE与其他FA核心蛋白(如BRCA2)协同调控DNA交联损伤修复的分子机制。
---
3. **文献名称**: *"Clinical and molecular features of Fanconi anemia: Role of FANCE mutations"*
**作者**: Shimamura, A. & D'Andrea, A.D.
**摘要**: 该文献通过患者样本中FANCE基因突变分析，结合抗体免疫印迹技术，阐明FANCE蛋白表达缺失与Fanconi贫血临床表型及染色体不稳定性的关联。
---
如需扩展检索，建议在PubMed或Google Scholar中以“FANCE antibody”或“Fanconi anemia gene E protein”为关键词筛选实验类论文。
The FANCE antibody is designed to detect the Fanconi anemia complementation group E (FANCE) protein, a critical component of the Fanconi anemia (FA) DNA repair pathway. FANCE plays a pivotal role in maintaining genomic stability by facilitating the assembly and function of the FA core complex, a multi-protein complex essential for repairing DNA interstrand crosslinks (ICLs). This complex coordinates the monoubiquitination of FANCD2 and FANCI, a key step in recruiting downstream repair factors. Mutations in the FANCE gene disrupt this pathway, leading to Fanconi anemia, a rare recessive disorder characterized by bone marrow failure, congenital abnormalities, and heightened cancer susceptibility.
FANCE antibodies are widely used in research to study FA pathway mechanisms, protein interactions, and DNA damage responses. They enable detection of FANCE expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the diagnosis of FA subtypes and functional studies in cellular models. Additionally, these antibodies contribute to exploring FANCE's role beyond FA, including its potential involvement in tumor suppression and chemotherapy resistance. As a research tool, FANCE antibodies help unravel molecular defects in FA and develop targeted therapies for FA-related malignancies and other genomic instability disorders.
×
