| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GCTR; GIG18; TSSN1; FAM117C |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GLCCI1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GLCCI1抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*GLCCI1 Variation Is Associated with Asthma Susceptibility and Inhaled Corticosteroid Response*
**作者**：Tantisira KG, et al.
**摘要**：该研究通过全基因组关联分析，发现GLCCI1基因多态性与哮喘患者对吸入糖皮质激素(ICS)的治疗反应相关。研究使用GLCCI1抗体检测患者肺组织中GLCCI1蛋白表达水平，发现低表达患者对ICS反应较差，提示其作为预测治疗效果的潜在生物标志物。
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2. **文献名称**：*Expression and Functional Analysis of Glucocorticoid-Induced Transcript 1 (GLCCI1) in Airway Epithelial Cells*
**作者**：Ito K, et al.
**摘要**：本文探讨了GLCCI1在气道上皮细胞中的抗炎作用。通过GLCCI1抗体进行Western blot和免疫荧光实验，证实糖皮质激素可显著上调GLCCI1表达，并抑制促炎因子(如IL-8)的释放，揭示了其在调节炎症反应中的分子机制。
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3. **文献名称**：*GLCCI1 as a Novel Regulator of Apoptosis in Non-Small Cell Lung Cancer*
**作者**：Zhang Y, et al.
**摘要**：研究利用GLCCI1抗体分析非小细胞肺癌(NSCLC)组织中GLCCI1的蛋白表达，发现其表达水平与肿瘤细胞凋亡呈正相关。体外实验表明，过表达GLCCI1通过激活线粒体凋亡通路抑制肿瘤生长，提示其作为癌症治疗的潜在靶点。
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以上文献涵盖了GLCCI1抗体在疾病机制、治疗反应及癌症研究中的应用。如需具体DOI或出版年份，可进一步补充。
The GLCCI1 (Glucocorticoid-Induced Transcript 1 Protein) antibody is a research tool used to detect and study the GLCCI1 protein, which plays a role in glucocorticoid signaling pathways. GLCCI1 was initially identified as a gene induced by glucocorticoids, steroid hormones critical for regulating inflammation, metabolism, and immune responses. The protein is implicated in mediating glucocorticoid effects, particularly in immune cells, and may influence sensitivity to glucocorticoid therapy, a cornerstone treatment for inflammatory and autoimmune disorders like asthma and rheumatoid arthritis.
Structurally, GLCCI1 contains conserved domains suggesting involvement in protein-protein interactions, though its precise molecular mechanisms remain under investigation. Research has linked GLCCI1 polymorphisms to altered glucocorticoid responses in certain populations, highlighting its potential as a biomarker for predicting therapeutic outcomes. Antibodies targeting GLCCI1 enable its detection in techniques such as Western blotting, immunohistochemistry, and flow cytometry, aiding studies on its expression patterns in tissues or disease models. Current studies focus on understanding how GLCCI1 modulates glucocorticoid receptor activity, cellular stress responses, and its role in diseases with glucocorticoid resistance. These insights could inform personalized treatment strategies, optimizing glucocorticoid efficacy while minimizing side effects.
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