| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PIF79; GMEB-2; P79PIF |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GMEB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GMEB2抗体的3篇参考文献示例(部分信息为示例性内容)：
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1. **文献名称**: *"GMEB2 modulates viral replication by regulating interferon signaling"*
**作者**: Tanaka K et al.
**摘要**: 本研究利用GMEB2抗体通过免疫沉淀和Western blot技术，发现GMEB2通过抑制I型干扰素通路促进RNA病毒复制，揭示其在宿主抗病毒反应中的调控作用。
2. **文献名称**: *"GMEB2 interacts with the glucocorticoid receptor to regulate stress response genes"*
**作者**: Müller S et al.
**摘要**: 通过ChIP-seq和免疫共沉淀(使用GMEB2抗体)，证明GMEB2与糖皮质激素受体结合，协同调控下游应激反应基因表达，影响细胞应激适应性。
3. **文献名称**: *"GMEB2 overexpression correlates with poor prognosis in hepatocellular carcinoma"*
**作者**: Chen L et al.
**摘要**: 采用GMEB2抗体进行免疫组化分析肝癌组织，发现GMEB2高表达与患者生存率降低相关，提示其作为肝癌潜在预后标志物的可能性。
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注：以上文献信息为示例性概括，实际文献需通过学术数据库(如PubMed)检索确认。如需具体文献，建议提供更详细的研究背景或访问相关数据库。
GMEB2 (Glucocorticoid Modulatory Element-Binding Protein 2) is a member of the GMEB family, which plays a regulatory role in glucocorticoid receptor (GR)-mediated gene transcription. Initially identified as a DNA-binding protein interacting with glucocorticoid modulatory elements, GMEB2 forms heterodimers with GMEB1 to enhance or repress GR-dependent transcriptional activity, depending on cellular context. It contains a Kruppel-associated box (KRAB) domain, suggesting potential involvement in chromatin remodeling or protein-protein interactions. Beyond glucocorticoid signaling, GMEB2 is implicated in diverse cellular processes, including viral response pathways, apoptosis regulation, and cell cycle control. Studies link it to adenovirus replication and interferon signaling modulation.
GMEB2 antibodies are essential tools for investigating its expression patterns, subcellular localization, and interactions in both physiological and pathological conditions. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research utilizing these antibodies has revealed GMEB2's widespread tissue distribution and dynamic expression during development or stress responses. Dysregulation of GMEB2 has been observed in certain cancers and autoimmune disorders, highlighting its potential therapeutic relevance. However, its precise mechanistic roles remain partially characterized, necessitating further study. Commercial GMEB2 antibodies are typically raised against specific epitopes within its N-terminal or central regions, with validation recommended for experimental applications.
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