| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GLUT8; GLUTX1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC2A8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC2A8抗体的3篇参考文献(内容基于公开研究整理，非真实文献)：
1. **文献名称**：*Role of SLC2A8 in Testicular Glucose Transport and Spermatogenesis*
**作者**：Li, X. et al.
**摘要**：通过免疫组化和Western blot分析，研究SLC2A8抗体在小鼠睾丸组织中的特异性表达，发现其定位于精子细胞，提示其在睾丸葡萄糖代谢和精子形成中的作用。
2. **文献名称**：*SLC2A8 Overexpression in Breast Cancer: A Prognostic Marker*
**作者**：Chen, Y. & Wang, H.
**摘要**：利用SLC2A8抗体对乳腺癌组织进行免疫染色，发现SLC2A8蛋白高表达与肿瘤转移和患者预后不良显著相关，提示其作为潜在治疗靶点。
3. **文献名称**：*SLC2A8 Antibody Validation in Neuronal Glucose Uptake Studies*
**作者**：Smith, J. et al.
**摘要**：验证SLC2A8抗体在大脑神经元中的特异性，证实其参与神经元葡萄糖转运，并发现其在阿尔茨海默病模型中的表达异常。
如需具体文献，建议通过PubMed或Google Scholar以“SLC2A8 antibody”或“GLUT8 antibody”为关键词检索。
The SLC2A8 antibody targets the solute carrier family 2 member 8 (SLC2A8), also known as glucose transporter 8 (GLUT8), encoded by the SLC2A8 gene. GLUT8 is a member of the facilitative glucose transporter (GLUT) family, which mediates cellular glucose uptake. Structurally, it contains 12 transmembrane domains characteristic of GLUT proteins. Unlike other GLUT isoforms, GLUT8 is primarily localized intracellularly, residing in endoplasmic reticulum, Golgi, or lysosomal membranes, and may require trafficking to the cell surface under specific conditions. It is highly expressed in testis, brain, liver, and adipose tissue, suggesting roles in energy metabolism and neuroendocrine function.
SLC2A8 antibodies are essential tools for studying GLUT8's physiological and pathological roles. Research indicates its involvement in insulin-regulated glucose transport, particularly in neurons and reproductive tissues. Dysregulation of GLUT8 has been linked to metabolic disorders, such as diabetes and obesity, as well as neurodegenerative diseases like Alzheimer's. In reproductive biology, GLUT8 is implicated in sperm maturation and ovarian follicle development.
Antibodies against SLC2A8 enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its expression patterns and subcellular localization. These studies help elucidate GLUT8's contribution to cellular glucose homeostasis and its potential as a therapeutic target. However, functional redundancy with other GLUT isoforms and context-dependent regulatory mechanisms necessitate careful validation of antibody specificity in experimental models.
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