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Rabbit Polyclonal GPR12 Antibody

  • 中文名： GPR12抗体
  • 别    名： GPCR12; GPCR21; PPP1R84
货号: IPDX06593
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesGPCR12; GPCR21; PPP1R84
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GPR12
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GPR12抗体的3篇示例文献(注：以下为虚构示例，实际文献需通过学术数据库查询)：

1. **文献名称**: *GPR12 Antibody Characterization in Neural Development*

**作者**: Smith A, et al.

**摘要**: 本研究验证了一种高特异性GPR12多克隆抗体在哺乳动物脑组织中的应用，发现GPR12在神经元突触生长中可能通过cAMP信号通路调控神经再生。

2. **文献名称**: *Role of GPR12 in Lipid Metabolism: Insights from Antibody-Based Knockdown*

**作者**: Lee J, et al.

**摘要**: 利用GPR12抗体阻断实验，发现GPR12在脂肪细胞分化中通过调控PPARγ活性影响脂质储存，提示其潜在代谢疾病治疗靶点价值。

3. **文献名称**: *GPR12 Antibody Reveals Localization in Ovarian Follicle Development*

**作者**: Chen R, et al.

**摘要**: 通过免疫组化结合GPR12抗体，证实GPR12在卵母细胞膜上高表达，可能参与生殖激素信号传导与卵泡成熟调控。

**建议**：实际研究中可查阅PubMed、Google Scholar等平台，或参考抗体供应商(如Abcam、Thermo Fisher)提供的技术文献。

背景信息

GPR12 (G Protein-Coupled Receptor 12) is an orphan receptor belonging to the rhodopsin-like GPCR family, initially identified through genomic studies. Though its endogenous ligands remain unclear, GPR12 is implicated in regulating neural development, synaptic plasticity, and metabolic processes. It shows high expression in the brain, particularly in regions like the hippocampus and cortex, as well as in adipose tissue and the cardiovascular system. Research suggests its involvement in neurite outgrowth, oligodendrocyte differentiation, and lipid metabolism regulation. GPR12 antibodies are essential tools for studying its localization, expression patterns, and functional roles. These antibodies, often developed in rabbits or mice, target specific epitopes (e.g., extracellular loops or C-terminal domains) and are validated via techniques like Western blotting, immunohistochemistry, or flow cytometry. Their applications span neuroscience (e.g., neurodevelopmental disorders), metabolic disease research (e.g., obesity, diabetes), and cancer studies, where aberrant GPR12 signaling may influence tumor progression. Challenges include verifying specificity due to GPCR structural homology and the receptor’s constitutive activity. Recent interest in GPR12 as a therapeutic target for neurological or metabolic disorders has driven demand for high-affinity antibodies to elucidate its signaling mechanisms and assess drug candidate interactions.

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