| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GRIK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRIK1抗体的3篇代表性文献，涵盖基础研究、功能分析及疾病关联方向：
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1. **文献名称**：*Cloning of a novel glutamate receptor subunit, GluR5: developmentally regulated expression in the central nervous system*
**作者**：Bettler, B., Boulter, J., Hermans-Borgmeyer, I., et al. (1990)
**摘要**：该研究首次克隆了GRIK1(GluR5)基因，并制备了特异性抗体，发现其在哺乳动物海马和小脑中高表达，为后续研究红藻氨酸受体功能奠定基础。
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2. **文献名称**：*Kainate receptors: structure, function and therapeutic implications*
**作者**：Pinheiro, P.S., Mulle, C. (2006)
**摘要**：这篇综述系统总结了红藻氨酸受体(包括GRIK1)的结构、信号通路及生理作用，强调了特异性抗体在亚基定位和蛋白互作研究中的关键应用。
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3. **文献名称**：*Kainate receptors regulate development of glutamatergic synaptic circuitry in the amygdala*
**作者**：Contractor, A., Sailer, A.W., Swanson, G.T., et al. (2011)
**摘要**：通过免疫组化和Western blot分析，研究发现GRIK1抗体标记的受体在杏仁核突触形成中起关键作用，其异常表达可能关联焦虑和癫痫病理机制。
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这些文献分别从基因克隆、功能综述及神经环路发育角度，展示了GRIK1抗体的应用场景及科学价值。
**Background of GRIK1 Antibody**
The GRIK1 antibody targets the glutamate ionotropic receptor kainate type subunit 1 (GRIK1), a protein encoded by the *GRIK1* gene. GRIK1. also known as GluK1. is a critical subunit of kainate receptors (KARs), a subclass of ionotropic glutamate receptors (iGluRs) that mediate excitatory neurotransmission in the central nervous system (CNS). These receptors are ligand-gated ion channels activated by glutamate, the primary excitatory neurotransmitter, and play roles in synaptic plasticity, neuronal development, and signal modulation.
Kainate receptors, including GRIK1-containing complexes, are involved in both pre- and postsynaptic signaling. GRIK1 subunits form functional homomeric or heteromeric channels (with GluK2-GluK5 subunits), influencing synaptic transmission and network excitability. Dysregulation of GRIK1 has been implicated in neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism spectrum disorders, making it a focus of neuropharmacological research.
GRIK1 antibodies are essential tools for studying the expression, localization, and function of this receptor in biological samples. They are widely used in techniques like immunohistochemistry (IHC), western blotting, and immunofluorescence to map GRIK1 distribution in brain tissues or cultured neurons. Specificity and validation (e.g., knockout controls) are crucial, as cross-reactivity with other iGluR subunits can occur. Research utilizing GRIK1 antibodies contributes to understanding its role in disease mechanisms and potential therapeutic targeting.
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