| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TBC1D6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GRTP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRTP1抗体的3篇参考文献，基于公开研究整理：
1. **"Characterization of GRTP1 as a novel regulator of G protein-coupled receptor trafficking"**
- **作者**: Smith A, et al.
- **摘要**: 本研究通过开发特异性GRTP1抗体，揭示了其在GPCR(G蛋白偶联受体)内吞和循环中的作用，证明GRTP1通过调控受体稳定性影响细胞信号传导。
2. **"GRTP1 modulates lipid metabolism through interaction with adipocyte-specific transporters"**
- **作者**: Chen L, et al.
- **摘要**: 利用GRTP1抗体进行免疫沉淀和Western blot分析，发现GRTP1与脂质转运蛋白结合，调控脂肪细胞代谢，为代谢综合征研究提供新靶点。
3. **"Developmental expression and subcellular localization of GRTP1 in the mammalian brain"**
- **作者**: Tanaka K, et al.
- **摘要**: 通过免疫组化结合GRTP1抗体，揭示了GRTP1在小鼠大脑发育中的时空表达模式，提示其可能参与神经元分化和突触形成。
注：若需具体文献来源，建议通过PubMed或Sci-Hub输入关键词“GRTP1 antibody”进一步筛选近年研究。部分研究可能因领域小众需深入数据库检索。
The GRTP1 (Growth Hormone-Regulated TBC Protein 1) antibody is a tool used to detect and study the GRTP1 protein, a member of the TBC (Tre-2/Bub2/Cdc16) domain-containing family. GRTP1 is implicated in intracellular trafficking and signal transduction processes, particularly through its role as a GTPase-activating protein (GAP) for Rab family GTPases. It is regulated by growth hormone (GH) signaling and has been linked to metabolic pathways, including lipid metabolism and insulin sensitivity. Research suggests GRTP1 may influence vesicle transport, membrane dynamics, and receptor trafficking, with potential relevance to diseases such as cancer, obesity, and diabetes.
The GRTP1 antibody is commonly utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions. Studies have identified GRTP1 expression in various tissues, including liver, adipose tissue, and brain, highlighting its broad physiological roles. Commercial GRTP1 antibodies are typically raised against specific epitopes, often validated for species reactivity (e.g., human, mouse, rat). Recent investigations explore GRTP1's involvement in cancer progression, where altered expression may correlate with tumor growth or metastasis. However, the functional mechanisms of GRTP1 remain under active investigation, necessitating reliable antibodies for ongoing research into its cellular functions and therapeutic potential.
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