| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HCCA2 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MOB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MOB2抗体的3篇参考文献示例(注：以下内容为虚构，仅用于示例)：
1. **文献名称**：*MOB2 regulates Hippo signaling through LATS kinase interaction*
**作者**：Garcia et al. (2018)
**摘要**：本研究利用MOB2特异性抗体进行免疫共沉淀和Western blot分析，揭示了MOB2在Hippo信号通路中通过结合LATS激酶调控细胞增殖和凋亡的分子机制。
2. **文献名称**：*MOB2 antibody-based profiling in breast cancer progression*
**作者**：Chen et al. (2020)
**摘要**：通过免疫组织化学(IHC)和MOB2抗体标记，发现MOB2在乳腺癌组织中的低表达与肿瘤转移相关，提示其作为潜在预后标志物的可能性。
3. **文献名称**：*Development and validation of a novel MOB2 monoclonal antibody*
**作者**：Kim et al. (2021)
**摘要**：报道了一种高特异性MOB2单克隆抗体的开发，并通过流式细胞术和免疫荧光验证其在细胞定位及蛋白互作研究中的应用效果。
4. **文献名称**：*MOB2 knockdown and antibody-mediated functional inhibition in glioblastoma*
**作者**：Smith et al. (2019)
**摘要**：结合MOB2抗体功能阻断实验，证明抑制MOB2可减少胶质母细胞瘤细胞的侵袭能力，并影响细胞周期蛋白依赖性激酶(CDK)的活性。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“MOB2 antibody”或“MOB2 function”。
MOB2 (Mps One Binder kinase activator-like 2) is a member of the evolutionarily conserved MOB protein family, which plays critical roles in cell cycle regulation, apoptosis, and signal transduction pathways, particularly the Hippo signaling pathway. Structurally, MOB2 lacks intrinsic enzymatic activity but functions as a scaffold or cofactor to modulate the activity of downstream kinases. It shares homology with MOB1. though their functional roles diverge. While MOB1 is a core component of the Hippo pathway, MOB2 is less characterized but has been implicated in regulating the NDR1/2 (Nuclear Dbf2-related) kinases, which influence centrosome duplication, mitotic progression, and neuronal development.
Research suggests MOB2 interacts with NDR kinases to form a complex involved in maintaining cell polarity and genomic stability. Dysregulation of MOB2 has been associated with cancer progression, with studies reporting its overexpression in certain tumors, potentially contributing to uncontrolled proliferation or metastasis. Additionally, MOB2 may intersect with mTOR signaling and DNA damage response pathways, though these mechanisms remain under investigation.
MOB2-specific antibodies are essential tools for studying its expression, localization, and interactions in cellular contexts. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore MOB2's role in physiological and pathological processes. Despite advances, the full scope of MOB2's functions and regulatory networks remains an active area of research, particularly in cancer biology and neurodevelopmental disorders.
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