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Rabbit Polyclonal MNX1 Antibody

  • 中文名： MNX1抗体
  • 别    名： HB9; HLXB9; SCRA1; HOXHB9
货号: IPDX06670
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHB9; HLXB9; SCRA1; HOXHB9
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MNX1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于MNX1抗体的3篇参考文献示例(文献信息为虚构，仅供示例参考)：

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1. **文献名称**：*MNX1 Expression in Pancreatic Development and Diabetes*

**作者**：Smith A, et al.

**摘要**：通过MNX1特异性抗体进行免疫组织化学分析，揭示其在胚胎胰腺β细胞分化中的动态表达模式，为研究糖尿病发病机制提供分子基础。

2. **文献名称**：*MNX1 as a Biomarker in Pediatric Medulloblastoma*

**作者**：Johnson B, et al.

**摘要**：利用MNX1抗体开展Western blot和免疫组化实验，发现MNX1在髓母细胞瘤中异常高表达，提示其可作为预后标志物及潜在治疗靶点。

3. **文献名称**：*MNX1 Localization in Mouse Neural Tube Development*

**作者**：Lee C, et al.

**摘要**：通过MNX1抗体的免疫荧光技术，证实MNX1在小鼠胚胎神经管运动神经元中的特异性表达，并验证其在神经发育中的关键调控作用。

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*注：以上文献信息为模拟生成，实际引用时需以真实发表的论文为准。建议通过PubMed或Google Scholar以关键词“MNX1 antibody”、“MNX1 immunohistochemistry”检索相关研究。*

背景信息

The MNX1 antibody targets the MNX1 (Motor Neuron and Pancreas Homeobox 1) protein, a transcription factor encoded by the MNX1 gene (previously known as HLXB9). MNX1 plays a critical role in embryonic development, particularly in motor neuron specification in the spinal cord and pancreatic β-cell differentiation. Dysregulation of MNX1 is linked to congenital disorders such as sacral agenesis and permanent neonatal diabetes mellitus. In research, MNX1 antibodies are essential tools for detecting and localizing the protein in tissues or cells via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. These antibodies help elucidate MNX1’s expression patterns, regulatory mechanisms, and pathological roles. MNX1 has also been implicated in cancer, with studies reporting its overexpression in certain tumors, including neuroendocrine tumors and leukemia, suggesting potential oncogenic functions. Commercially available MNX1 antibodies are typically monoclonal or polyclonal, raised in hosts like rabbits or mice, and require validation for specificity and sensitivity. Their applications span developmental biology, diabetes research, and oncology, aiding in both diagnostic and mechanistic studies. However, variability in antibody performance across experimental conditions underscores the need for rigorous optimization in different assays. Overall, MNX1 antibodies remain vital for advancing understanding of developmental and disease processes associated with this transcription factor.

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