Rabbit Polyclonal GTF2H4 Antibody

The GTF2H4 antibody targets the General Transcription Factor IIH subunit 4 (GTF2H4), a critical component of the transcription factor IIH (TFIIH) complex. TFIIH plays dual roles in transcription initiation by RNA polymerase II and nucleotide excision repair (NER), a DNA repair pathway. GTF2H4. also known as p52. stabilizes the TFIIH complex and facilitates its recruitment to transcription or repair sites. It interacts with other TFIIH subunits, such as p62 and XPB, to regulate DNA unwinding during transcription and damage recognition in NER. Antibodies against GTF2H4 are widely used in research to study TFIIH assembly, transcription mechanisms, and DNA repair processes. They are applied in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess protein expression, localization, and interactions. Dysregulation of TFIIH is linked to diseases, including xeroderma pigmentosum and Cockayne syndrome, though GTF2H4 mutations are less commonly implicated. Commercially available GTF2H4 antibodies are typically validated in knockout or knockdown models to ensure specificity. Studying GTF2H4 helps elucidate cellular responses to DNA damage and transcriptional dysregulation in cancer or genetic disorders.