Rabbit Polyclonal HLA-DPA1 Antibody

The HLA-DPA1 gene, part of the human leukocyte antigen (HLA) class II complex on chromosome 6p21.3. encodes the alpha chain of the HLA-DP heterodimer, which plays a critical role in antigen presentation to CD4+ T cells. HLA-DPA1 combines with HLA-DPB1 to form functional HLA-DP molecules that bind exogenous peptides and initiate adaptive immune responses. Antibodies targeting HLA-DPA1 are primarily studied in autoimmune diseases, transplantation, and infectious immunity. In autoimmune contexts, such as rheumatoid arthritis or celiac disease, anti-HLA-DPA1 antibodies may contribute to pathogenic immune activation by disrupting antigen presentation or promoting inflammation. In transplantation, these antibodies are associated with graft rejection, as HLA-DP mismatches can trigger alloreactive responses. HLA-DPA1 antibodies also serve as research tools to investigate HLA-DP expression patterns, allele-specific interactions, and disease associations. Their detection in clinical settings, often via Luminex-based assays or flow cytometry, aids in assessing alloimmunization risks or diagnosing antibody-mediated conditions. Additionally, HLA-DPA1 polymorphisms influence disease susceptibility and drug responses, making these antibodies relevant in pharmacogenomics. Research continues to explore their mechanistic roles in immune regulation and therapeutic potential.