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Rabbit Polyclonal HLA-DPA1 Antibody

  • 中文名： HLA-DPA1抗体
  • 别    名： PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
货号: IPDX06695
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
WB Predicted band size29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HLA-DPA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于HLA-DPA1抗体的3篇示例文献(内容为模拟概括，仅供参考)：

1. **文献名称**：*HLA-DPA1 antibodies in renal transplant rejection: clinical significance and epitope analysis*

**作者**：Smith J, et al.

**摘要**：探讨HLA-DPA1抗体在肾移植排斥反应中的作用，发现其与移植物功能延迟恢复相关，并通过表位定位揭示抗体靶向的HLA-DPA1特异性区域。

2. **文献名称**：*Autoantibodies against HLA-DPA1 in systemic sclerosis: association with pulmonary fibrosis*

**作者**：Lee S, et al.

**摘要**：研究系统性硬化症患者中HLA-DPA1自身抗体的存在，发现其阳性率与肺纤维化严重程度显著相关，提示可能作为疾病进展的生物标志物。

3. **文献名称**：*High-throughput detection of HLA-DPA1 antibodies using Luminex-based multiplex assays*

**作者**：Wang Y, et al.

**摘要**：开发基于Luminex平台的HLA-DPA1抗体检测方法，验证其敏感性和特异性，为移植前供受体配型及抗体监测提供技术支持。

注：以上文献信息为示例性概括，实际研究中请通过PubMed或学术数据库检索真实发表文献。

背景信息

The HLA-DPA1 gene, part of the human leukocyte antigen (HLA) class II complex on chromosome 6p21.3. encodes the alpha chain of the HLA-DP heterodimer, which plays a critical role in antigen presentation to CD4+ T cells. HLA-DPA1 combines with HLA-DPB1 to form functional HLA-DP molecules that bind exogenous peptides and initiate adaptive immune responses. Antibodies targeting HLA-DPA1 are primarily studied in autoimmune diseases, transplantation, and infectious immunity. In autoimmune contexts, such as rheumatoid arthritis or celiac disease, anti-HLA-DPA1 antibodies may contribute to pathogenic immune activation by disrupting antigen presentation or promoting inflammation. In transplantation, these antibodies are associated with graft rejection, as HLA-DP mismatches can trigger alloreactive responses. HLA-DPA1 antibodies also serve as research tools to investigate HLA-DP expression patterns, allele-specific interactions, and disease associations. Their detection in clinical settings, often via Luminex-based assays or flow cytometry, aids in assessing alloimmunization risks or diagnosing antibody-mediated conditions. Additionally, HLA-DPA1 polymorphisms influence disease susceptibility and drug responses, making these antibodies relevant in pharmacogenomics. Research continues to explore their mechanistic roles in immune regulation and therapeutic potential.

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