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Rabbit Polyclonal TRMT112 Antibody

  • 中文名: TRMT112抗体
  • 别    名: TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2
货号: IPDX06719
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于TRMT112抗体的3篇参考文献示例(注:文献为虚拟构造,实际引用需核实):

1. **文献名称**: "TRMT112 interacts with the NSUN5–TRMT112 complex and mediates ribosomal RNA methylation"

**作者**: Garcia et al.

**摘要**: 本研究利用兔源多克隆TRMT112抗体,通过免疫共沉淀和Western blot技术,揭示了TRMT112与NSUN5蛋白的相互作用,并证明其在核糖体RNA甲基化修饰中的关键作用。

2. **文献名称**: "Characterization of a monoclonal antibody against human TRMT112 for functional studies in cell proliferation"

**作者**: Wang et al.

**摘要**: 报道了一种高特异性小鼠单克隆TRMT112抗体的开发,通过免疫荧光和流式细胞术验证其在HeLa细胞中的定位,并发现TRMT112敲低导致细胞周期阻滞。

3. **文献名称**: "TRMT112 regulates Wnt/β-catenin signaling via interaction with METTL1"

**作者**: Tanaka et al.

**摘要**: 使用商品化TRMT112抗体(Abcam货号XX)进行免疫印迹分析,发现TRMT112与METTL1共同调控Wnt通路,影响结直肠癌细胞增殖。

4. **文献名称**: "Antibody-based profiling of TRMT112 expression in human tissues"

**作者**: Rodriguez et al.

**摘要**: 通过组织微阵列和免疫组化技术,系统分析了TRMT112抗体在多种正常和肿瘤组织中的表达谱,提示其作为潜在生物标志物的价值。

建议通过PubMed或Google Scholar以“TRMT112 antibody”为关键词检索真实文献,并关注抗体应用场景(如WB、IP、IF等)。

背景信息

The TRMT112 antibody is a valuable tool for studying the TRMT112 protein, a highly conserved methyltransferase adaptor involved in RNA modification and cellular processes. TRMT112 (tRNA methyltransferase 112) acts as a binding partner for multiple enzymes, including tRNA methyltransferases (e.g., TRMT11. TRMT112-TRMT11 complex) and the 18S rRNA methyltransferase WBSCR22. facilitating their stability and catalytic activity. It plays a critical role in post-transcriptional RNA modifications, such as N2-methylguanosine (m2G) and N7-methylguanosine (m7G), which are essential for ribosome biogenesis, tRNA maturation, and translational fidelity. Dysregulation of TRMT112 has been linked to neurodevelopmental disorders (e.g., Williams-Beuren syndrome) and cancer progression. The TRMT112 antibody enables detection and quantification of TRMT112 expression in various experimental models (e.g., Western blot, immunofluorescence), aiding research on its molecular interactions, tissue distribution, and pathological mechanisms. Its specificity for human, mouse, and rat homologs makes it widely applicable in studies of RNA epigenetics, gene regulation, and disease biomarkers.

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