| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CP11; HOX3; HOX3D |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及HOXC5抗体的代表性文献(信息为虚构模拟，供参考)：
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1. **文献名称**: HOXC5 promotes colorectal cancer metastasis via transcriptional activation of EMT-related genes
**作者**: Li X, et al.
**摘要**: 本研究通过免疫组化(HOXC5抗体：Abcam, ab12345)发现HOXC5在结直肠癌转移灶中高表达，其表达水平与患者预后负相关。体外实验证实HOXC5通过调控Snail和Twist1基因促进上皮间质转化(EMT)。
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2. **文献名称**: HOXC5 antibody-based profiling reveals its role in neural stem cell differentiation
**作者**: Smith J, et al.
**摘要**: 利用特异性HOXC5抗体(Santa Cruz, sc-7890)进行免疫荧光和Western blot分析，发现HOXC5在神经干细胞向神经元分化过程中显著上调，并通过抑制Wnt/β-catenin通路调控分化进程。
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3. **文献名称**: HOXC5 as a biomarker in triple-negative breast cancer: immunohistochemical validation
**作者**: Gupta R, et al.
**摘要**: 本研究采用商业化HOXC5抗体(Cell Signaling Technology, #23456)对120例三阴性乳腺癌组织进行染色，证实HOXC5高表达与化疗耐药性相关，并可能作为潜在治疗靶点。
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注：以上文献信息为示例性质，实际引用需根据具体研究通过PubMed或Google Scholar检索验证。建议使用关键词"HOXC5 antibody" + 研究领域(如cancer/differentiation)筛选近年高引论文。
The HOXC5 antibody is a research tool designed to detect and study the HOXC5 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body segmentation and patterning along the anterior-posterior axis. HOXC5. located on chromosome 12 in humans, plays roles in cellular differentiation, proliferation, and tissue-specific identity. Dysregulation of HOXC5 has been implicated in various cancers, including leukemia, breast cancer, and prostate cancer, where it may act as an oncogene or tumor suppressor depending on context.
HOXC5 antibodies are typically produced in host species (e.g., rabbits, mice) using immunogenic peptides or recombinant HOXC5 protein fragments. These antibodies enable researchers to investigate HOXC5 expression, localization, and function via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Validation steps, such as knockout controls or siRNA knockdown, are essential to confirm specificity due to potential cross-reactivity with other HOX family members.
Studies utilizing HOXC5 antibodies have shed light on its involvement in developmental pathways, cancer progression, and interactions with signaling molecules like Wnt or TGF-β. Recent research also explores its role in non-cancer contexts, such as neural development and wound healing. As with many HOX proteins, HOXC5’s functional complexity underscores the importance of reliable antibodies for dissecting its multifaceted contributions to biology and disease.
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