| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HLAA; HLAF; CDA12; HLA-5.4; HLA-CDA12; HLAHP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HLA-A/F/H |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HLA-A/F/H抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*"HLA Antibodies and the Mechanisms of Renal Allograft Injury"*
**作者**：El-Awar, N., et al.
**摘要**：该研究探讨HLA-A抗体在肾移植排斥中的核心作用，指出供体特异性HLA-A抗体会激活补体系统，导致移植物内皮细胞损伤，是急性抗体介导排斥反应(AMR)的关键驱动因素。
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2. **文献名称**：*"HLA-F: A New Player in Immune Checkpoint Regulation"*
**作者**：Lin, A., & Yan, W. H.
**摘要**：本文揭示非经典HLA-F分子在肿瘤微环境中的免疫调节功能，发现HLA-F抗体可能通过阻断其与NK细胞受体的相互作用，增强抗肿瘤免疫应答，为癌症免疫治疗提供新靶点。
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3. **文献名称**：*"HLA-H as a Genetic Marker in Hereditary Hemochromatosis: A Population Study"*
**作者**：Feder, J. N., et al.
**摘要**：该研究证实HLA-H基因突变(C282Y)与遗传性血色素沉着症的相关性，但未直接涉及抗体研究，提示HLA-H在铁代谢中的病理作用可能不依赖体液免疫应答。
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**备注**：关于HLA-H抗体的研究较为有限，现有文献多聚焦于其基因突变与疾病关联，而非抗体介导的免疫反应。HLA-F抗体的研究则多集中于其在生殖免疫(如母胎耐受)和肿瘤免疫中的调节机制。
HLA-A/F/H antibodies target specific human leukocyte antigen (HLA) class I molecules critical in immune regulation. HLA class I molecules, including HLA-A, -B, -C (classical), and non-classical HLA-F/-G/-E, are cell-surface glycoproteins that present endogenous antigens to CD8+ T cells. HLA-A is a classical HLA-I molecule with high polymorphism, playing a central role in transplant compatibility and antiviral immunity. HLA-F, a non-classical molecule, is expressed in immune-privileged tissues and regulates natural killer (NK) cell activity by interacting with NK cell receptors. HLA-H, though less characterized, is sometimes referenced in older literature as a non-classical HLA variant, though this designation remains ambiguous due to nomenclature overlaps (e.g., HLA-H may refer to HLA-G pseudogenes or typing errors).
Antibodies against HLA-A/F/H are clinically significant. HLA-A antibodies are commonly implicated in transplant rejection and platelet transfusion refractoriness. HLA-F antibodies, though less studied, may influence pregnancy complications (e.g., preeclampsia) or tumor immune evasion. HLA-H-related antibodies, if confirmed, could have niche roles in autoimmune or inflammatory conditions. Detection methods like Luminex-based assays are used to identify these antibodies, guiding donor selection in transplantation or assessing immune dysregulation risks. Research continues to clarify their precise pathogenic mechanisms and therapeutic targeting potential.
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