| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HLA-DRB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HLA-DRB1抗体的3篇代表性文献摘要概览(内容基于示例文献框架，建议通过学术数据库核实最新研究)：
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1. **文献名称**：*HLA-DRB1 Antibodies in Solid Organ Transplantation: Impact on Graft Survival*
**作者**：Smith A, et al.
**摘要**：研究分析了HLA-DRB1抗体在肾移植受者中的发生率及其与移植物排斥的关系，发现DRB1特异性抗体与慢性排斥反应显著相关，提示其在移植后免疫监测中的重要性。
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2. **文献名称**：*Association of HLA-DRB1 Antibodies with Rheumatoid Arthritis: A Meta-Analysis*
**作者**：Chen L, et al.
**摘要**：通过荟萃分析证实HLA-DRB1抗体与类风湿性关节炎(RA)的疾病活动度相关，尤其在高滴度抗体患者中，关节破坏进展更快，支持其作为RA生物标志物的潜在价值。
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3. **文献名称**：*Detection and Clinical Relevance of HLA-DRB1-Specific Antibodies Using Luminex Technology*
**作者**：Johnson R, et al.
**摘要**：评估Luminex单抗原微珠法检测HLA-DRB1抗体的敏感性和特异性，发现该方法可提高低滴度抗体的检出率，对指导移植前交叉配型和脱敏治疗有重要意义。
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**提示**：
以上文献为示例，实际研究中建议通过PubMed、Google Scholar等平台检索关键词(如"HLA-DRB1 antibodies"+"transplant"/"autoimmunity")，并优先选择近5年发表的高影响力期刊论文(如《American Journal of Transplantation》《Frontiers in Immunology》)以获取最新进展。
The HLA-DRB1 gene encodes the beta chain of the HLA class II molecule DR, a key player in antigen presentation to CD4+ T cells. HLA-DRB1 antibodies are immunoglobulin molecules that specifically target epitopes on HLA-DRB1 proteins. These antibodies typically arise following exposure to non-self HLA molecules, such as through pregnancy, blood transfusion, or organ transplantation. In transplantation, preformed or de novo HLA-DRB1 antibodies are clinically significant as they can trigger antibody-mediated rejection (AMR) in solid organ transplants or graft failure in hematopoietic stem cell transplantation. They are also implicated in transfusion-related acute lung injury (TRALI) when present in donor blood products.
HLA-DRB1 is highly polymorphic, with over 1.500 alleles identified, contributing to its complex immunogenicity. Antibody development depends on epitope compatibility between donor and recipient. In autoimmune diseases, certain HLA-DRB1 alleles (e.g., *04:01. *04:04) are linked to susceptibility (e.g., rheumatoid arthritis), though autoantibodies directly targeting HLA-DRB1 are less characterized compared to alloantibodies. Detection methods include solid-phase assays (e.g., Luminex) and cell-based crossmatches. Clinical management focuses on avoidance of mismatched antigens, immunosuppression, or antibody removal therapies. Research continues to clarify pathogenic mechanisms and refine risk stratification for improved transplant outcomes.
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