| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX3; HOC3F; HOX3F |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXC12抗体的模拟参考文献示例(注：以下文献信息为虚构，仅作格式参考，建议通过PubMed或Google Scholar查询真实文献)：
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1. **文献名称**: "HOXC12 Antibody Validation in Developmental Models"
**作者**: Thompson R, et al.
**摘要**: 本研究利用HOXC12特异性抗体，通过免疫组化和小鼠胚胎模型验证了其在肢体发育中的表达模式，证实抗体在识别HOXC12蛋白亚细胞定位中的可靠性，并发现HOXC12异常表达与骨骼发育缺陷相关。
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2. **文献名称**: "HOXC12 as a Biomarker in Colorectal Cancer Progression"
**作者**: Lee S, Zhang Y.
**摘要**: 通过Western blot和免疫荧光技术，使用HOXC12抗体检测结直肠癌组织样本，发现HOXC12高表达与肿瘤侵袭性及患者预后不良显著相关，提示其可能成为潜在治疗靶点。
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3. **文献名称**: "Epigenetic Regulation of HOXC12 in Breast Cancer"
**作者**: Gupta M, et al.
**摘要**: 研究采用HOXC12抗体进行染色质免疫沉淀(ChIP)，揭示了DNA甲基化与HOXC12在乳腺癌中的转录沉默机制，为表观遗传调控肿瘤转移提供了新证据。
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4. **文献名称**: "HOXC12 Knockout Models and Antibody Cross-Reactivity Analysis"
**作者**: Chen L, et al.
**摘要**: 通过构建HOXC12基因敲除小鼠模型，验证了多种商业化HOXC12抗体的特异性，发现部分抗体存在与非目标HOX家族蛋白的交叉反应，强调了抗体验证的重要性。
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如需实际文献，建议在学术数据库中以“HOXC12 antibody”、“HOXC12 function”或“HOXC12 cancer”为关键词检索。
The HOXC12 antibody is a research tool designed to detect the HOXC12 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body axis patterning, organogenesis, and limb formation. HOXC12. located on chromosome 12 within the HOXC cluster, contains a conserved homeodomain that binds DNA to regulate target gene expression. It plays roles in skeletal development, cell differentiation, and tissue remodeling, with expression patterns often tissue- and stage-specific.
HOXC12 antibodies are widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) to study HOXC12’s spatial-temporal expression, localization, and interactions in developmental and disease contexts. Dysregulation of HOXC12 has been linked to cancers (e.g., breast, prostate, and leukemia) due to its influence on proliferation, apoptosis, and metastasis. Antibodies enable researchers to explore HOXC12’s oncogenic or tumor-suppressive roles, depending on cellular context.
Additionally, HOXC12 antibodies aid in understanding congenital disorders. Mutations or aberrant HOXC12 expression correlate with skeletal malformations and neurological defects. Recent studies also implicate HOXC12 in metabolic regulation and stem cell maintenance, expanding its relevance beyond developmental biology. As a reagent, HOXC12 antibodies must be validated for specificity, as cross-reactivity with other HOX proteins is a common challenge. Their application continues to advance insights into HOX-mediated gene networks and therapeutic targeting opportunities.
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