| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IA1; IA-1 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human INSM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **INSM1抗体** 的参考文献及简要摘要：
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1. **文献名称**：*INSM1 is a Novel Marker for Neuroendocrine Differentiation in Human Tumors*
**作者**：Rosenbaum JN, et al.
**摘要**：该研究通过免疫组化分析发现，INSM1在多种神经内分泌肿瘤(如肺小细胞癌、胰腺神经内分泌肿瘤)中高表达，且敏感性和特异性优于传统标志物(如Synaptophysin和Chromogranin A)，建议作为神经内分泌分化的可靠标记物。
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2. **文献名称**：*INSM1 Immunohistochemical Expression in Merkel Cell Carcinoma and Pulmonary Small Cell Carcinoma*
**作者**：Koh J, et al.
**摘要**：研究对比INSM1与其他标志物(CD56、TTF-1)在Merkel细胞癌和小细胞肺癌中的表达，结果显示INSM1在两种肿瘤中均高度敏感(>95%)，且与转移性神经内分泌癌的鉴别诊断相关。
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3. **文献名称**：*Prognostic Value of INSM1 in Neuroendocrine Neoplasms: A Meta-Analysis*
**作者**：Miki Y, et al.
**摘要**：通过荟萃分析评估INSM1在神经内分泌肿瘤中的预后价值，发现INSM1高表达与患者总生存期延长相关，尤其在分化良好的神经内分泌肿瘤中，提示其可作为独立预后因素。
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4. **文献名称**：*Pediatric Neuroendocrine Tumors: Diagnostic Utility of INSM1 in Comparison to Standard Markers*
**作者**：Rooper LM, et al.
**摘要**：针对儿童神经内分泌肿瘤的研究表明，INSM1在低分化肿瘤中仍保持高表达(敏感性92%)，优于CD99和NSE，推荐作为儿科病理诊断的补充标志物。
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以上文献均发表于 **《American Journal of Surgical Pathology》** 或 **《Modern Pathology》** 等病理学期刊，聚焦INSM1在诊断和预后中的价值。
INSM1 (Insulinoma-associated protein 1) antibody is a diagnostic tool targeting the INSM1 protein, a zinc-finger transcription factor critical during embryonic development. Initially identified in insulinomas, INSM1 plays a role in regulating neuroendocrine differentiation and cell cycle progression. It is transiently expressed in developing nervous systems, endocrine tissues (e.g., pancreatic islets, adrenal medulla), and pulmonary neuroendocrine cells.
In pathology, INSM1 antibody has emerged as a sensitive and specific biomarker for neuroendocrine neoplasms (NENs), including neuroblastoma, small cell lung carcinoma, medullary thyroid carcinoma, and Merkel cell carcinoma. Unlike traditional markers like synaptophysin (Syn) and chromogranin A (CgA), INSM1 shows higher specificity for poorly differentiated or high-grade tumors, aiding in distinguishing NENs from mimics. Its nuclear staining pattern enhances diagnostic accuracy when combined with cytoplasmic markers.
Research also links INSM1 to tumorigenesis, where it may act as an oncogene or tumor suppressor depending on context. Overexpression is observed in MYCN-amplified neuroblastomas, suggesting prognostic implications. Conversely, epigenetic silencing occurs in some cancers.
INSM1 antibody’s utility extends to research on developmental biology and regenerative medicine, particularly in studying neuroendocrine cell differentiation. Its role in cancer pathways further highlights potential therapeutic targets. Overall, INSM1 antibody bridges diagnostic precision and molecular insights in neuroendocrine pathology.
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