Rabbit Polyclonal INSM2 Antibody

The INSM2 (Insulinoma-associated protein 2) antibody is a tool used to study the INSM2 protein, a member of the zinc-finger transcription factor family. First identified in neuroendocrine tumors, INSM2 shares structural homology with other INSM family proteins (INSM1-5), characterized by conserved N-terminal zinc-binding domains and C-terminal proline-rich regions. While INSM1 is widely recognized as a marker for neuroendocrine differentiation (e.g., in neuroblastoma and Merkel cell carcinoma), INSM2’s role remains less explored. Studies suggest INSM2 is critical during embryonic development, particularly in regulating cell proliferation and differentiation in neural and endocrine tissues. It is also implicated in tumorigenesis, with overexpression observed in certain cancers, such as neuroendocrine tumors, lung cancer, and hepatocellular carcinoma. Functionally, INSM2 acts as a transcriptional repressor, interacting with chromatin-modifying complexes to silence genes involved in cell cycle progression. Antibodies targeting INSM2 are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess its expression patterns and subcellular localization. Research continues to uncover its potential as a diagnostic biomarker or therapeutic target, though its mechanisms and interactions remain less defined compared to INSM1.