关键信息
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基因名
IL-23R
- 应用
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q5VWK5
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表达区间
Gly24~Gly355
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分子量
60kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-23 receptor (IL-23R) is a critical component of the immune system, playing a significant role in the regulation of inflammatory responses. It primarily binds to interleukin-23 (IL-23), a cytokine involved in the differentiation and proliferation of T-helper 17 (Th17) cells, which are crucial in various autoimmune diseases, including psoriasis, inflammatory bowel disease, and multiple sclerosis. Studies have shown that genetic polymorphisms in the IL-23R gene are associated with an increased susceptibility to these conditions, highlighting its importance as a therapeutic target. The production of recombinant IL-23R protein can provide valuable insights into its structure and function, enabling researchers to explore its signaling pathways and interactions with IL-23. This recombinant protein can be used in various applications, including drug development and the creation of targeted therapies that modulate immune responses. Understanding the role of IL-23R in chronic inflammation and autoimmune disorders could lead to the development of novel therapeutic strategies aimed at mitigating these conditions, thereby improving patient outcomes.
