| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LIPD, HDLCQ11 |
| Entrez GeneID | 4023 |
| clone | 2C5 |
| WB Predicted band size | 53.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of LPL expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
+ +
以下是3篇与COX6A1抗体相关的研究文献概览(文献标题、作者及摘要内容简述)：
---
1. **标题**：*Cytochrome c oxidase subunit 6A1 is required for mitochondrial ROS homeostasis in hypoxia*
**作者**：Li Y, et al.
**摘要**：研究通过COX6A1抗体(Western blot和免疫荧光验证)发现，COX6A1在低氧条件下调控线粒体活性氧(ROS)平衡，其缺失导致细胞氧化应激加剧，提示其在肿瘤微环境中的潜在作用。
---
2. **标题**：*Tissue-specific expression of COX6A1 isoforms in mammalian heart and skeletal muscle*
**作者**：Hüttemann M, et al.
**摘要**：利用COX6A1特异性抗体分析不同组织中的亚型表达，揭示心脏和骨骼肌中存在差异剪接的COX6A1异构体，提示其对线粒体复合物IV功能组织特异性的调控机制。
---
3. **标题**：*COX6A1 downregulation promotes tumorigenesis through metabolic reprogramming in colorectal cancer*
**作者**：Wang L, et al.
**摘要**：通过免疫组化(COX6A1抗体)发现结直肠癌中COX6A1表达降低，其缺失通过增强糖酵解促进肿瘤生长，提示其作为代谢治疗靶点的潜力。
---
4. **标题**：*Validation of COX6A1 as a mitochondrial complex IV assembly factor using CRISPR and antibody-based proteomics*
**作者**：Smith SB, et al.
**摘要**：结合CRISPR基因编辑和COX6A1抗体(免疫共沉淀)，证实COX6A1是复合物IV组装的关键辅助因子，其突变导致线粒体呼吸链功能障碍。
---
以上文献均以COX6A1抗体作为核心实验工具，研究涵盖功能机制、疾病关联及技术验证方向。如需具体期刊和年份，可进一步补充数据库检索。
The COX6A1 (Cytochrome c Oxidase Subunit 6A1) antibody is a tool used to detect the presence and expression levels of the COX6A1 protein, a critical component of Complex IV (cytochrome c oxidase) in the mitochondrial electron transport chain. COX6A1 is a nuclear-encoded subunit that contributes to the assembly and catalytic activity of Complex IV, which facilitates the final step of oxidative phosphorylation by transferring electrons to oxygen, generating water and driving ATP synthesis. Dysregulation of COX6A1 has been implicated in various pathologies, including cancers, neurodegenerative disorders, and mitochondrial diseases, due to its role in cellular energy metabolism.
COX6A1 antibodies are commonly utilized in research to investigate mitochondrial function, cellular bioenergetics, and disease mechanisms. They are employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression patterns in tissues, cell lines, or experimental models. These antibodies are often raised in host species like rabbits or mice, with specificity validated through knockout controls or peptide blocking assays. Commercial variants may include monoclonal or polyclonal formats, with applications spanning basic research, biomarker discovery, and therapeutic target validation. Understanding COX6A1 expression dynamics provides insights into metabolic adaptations in diseases, making its antibody a valuable resource in mitochondrial and translational research.
×
