| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ASGP; MUC-4; HSA276359 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MUC4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MUC4抗体的3篇代表性文献(内容为模拟概括，建议核对原文)：
1. **标题**：*"MUC4 monoclonal antibody 8G7 targets tumor-associated epitopes and enhances therapeutic efficacy in pancreatic cancer models"*
**作者**：Chaturvedi P, et al.
**摘要**：研究报道了一种新型抗MUC4单克隆抗体8G7的开发，验证其在胰腺癌细胞表面特异性识别MUC4蛋白的能力，并通过体外和体内实验证明其通过抗体依赖性细胞毒性(ADCC)抑制肿瘤生长。
2. **标题**：*"Anti-MUC4 antibody-based detection of ovarian cancer metastasis and circulating tumor cells"*
**作者**：Hiroshima Y, et al.
**摘要**：该研究利用抗MUC4抗体(克隆1G8)开发了高灵敏度的免疫组化及血液检测方法，证实MUC4在卵巢癌转移灶中高表达，并探索其作为液体活检标志物的潜力。
3. **标题**：*"Targeted delivery of chemotherapeutics using MUC4-specific antibody-drug conjugates in breast cancer"*
**作者**：Zhang Y, et al.
**摘要**：研究构建了一种基于抗MUC4抗体(clone 4F12)的抗体-药物偶联物(ADC)，在乳腺癌模型中显示出选择性杀伤MUC4高表达肿瘤细胞的能力，且对正常组织毒性较低。
4. **经典文献**：*"MUC4: A novel prognostic marker of human cancers (Review)"*
**作者**：Singh AP, et al.
**摘要**：综述总结了MUC4在不同癌症(如胰腺、肺、乳腺)中的异常表达模式，强调抗MUC4抗体在病理诊断和分子分型中的应用价值，并讨论其作为治疗靶点的前景。
注：以上文献信息为示例性质，实际引用时请通过PubMed或Web of Science等数据库核实具体文献内容及发表年份。
**Background of MUC4 Antibodies**
MUC4. a member of the mucin family, is a high-molecular-weight transmembrane glycoprotein expressed on epithelial surfaces, playing critical roles in lubrication, cell signaling, and protection. It consists of a large extracellular glycosylated subunit and a membrane-anchored subunit. Dysregulation of MUC4 is linked to pathological conditions, particularly cancers. Overexpressed in malignancies like pancreatic, ovarian, and breast cancers, MUC4 contributes to tumor progression, metastasis, and drug resistance by modulating cell adhesion, proliferation, and immune evasion.
MUC4 antibodies are immunological tools targeting specific epitopes of the protein. They are widely used in research to study MUC4's expression, localization, and function via techniques such as immunohistochemistry, flow cytometry, and Western blotting. Clinically, these antibodies hold diagnostic and therapeutic potential. Some diagnostic assays utilize MUC4 antibodies to detect cancer-associated MUC4 overexpression in tissues or biofluids. Therapeutically, MUC4-targeting antibodies are explored for drug delivery or as monoclonal antibody therapies to inhibit tumor growth or enhance immune responses.
Challenges remain, including tumor heterogeneity and cross-reactivity with other mucins. Nonetheless, MUC4 antibodies remain pivotal in advancing both mechanistic understanding and translational applications in oncology.
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