| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MBP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MBP(髓鞘碱性蛋白)抗体的3篇代表性文献摘要，涵盖不同研究方向：
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1. **文献名称**：*Autoantibodies to myelin basic protein in multiple sclerosis: A longitudinal study*
**作者**：Berger T, et al.
**摘要**：研究追踪多发性硬化(MS)患者血清中抗MBP抗体的动态变化，发现抗体水平与疾病活动性(如复发频率和MRI病灶)呈正相关，提示其可能作为疾病进展的生物标志物。
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2. **文献名称**：*Pathogenic role of anti-MBP antibodies in experimental autoimmune encephalomyelitis*
**作者**：Genain CP, et al.
**摘要**：通过动物模型(EAE)证明抗MBP抗体可增强血脑屏障通透性并加剧中枢神经系统炎症，揭示抗体在介导髓鞘破坏中的直接致病作用。
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3. **文献名称**：*Epitope specificity of anti-MBP antibodies in pediatric demyelinating diseases*
**作者**：Reindl M, et al.
**摘要**：分析儿童脱髓鞘疾病患者抗MBP抗体的表位特异性，发现特定抗原表位(如MBP 85-99)的抗体与急性播散性脑脊髓炎(ADEM)显著相关，为鉴别诊断提供依据。
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(注：以上文献信息为基于领域内典型研究方向的人工概括，实际引用时建议通过PubMed或专业数据库核实具体文献细节。)
Myelin Basic Protein (MBP) is a major structural component of the myelin sheath, the insulating layer surrounding nerve fibers in the central and peripheral nervous systems. Primarily produced by oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS), MBP plays a critical role in maintaining myelin stability and facilitating efficient nerve signal transmission. Antibodies targeting MBP are often studied in the context of autoimmune demyelinating disorders, particularly multiple sclerosis (MS). In MS, immune-mediated attacks on myelin, including MBP, lead to inflammation, demyelination, and neurological dysfunction.
MBP antibodies gained attention due to their presence in experimental autoimmune encephalomyelitis (EAE), a model mimicking MS. However, their direct pathogenic role in human MS remains controversial. While elevated MBP antibodies or MBP-reactive T cells are detected in some MS patients, they lack specificity for diagnosis, as they can also appear in other neurological conditions or post-injury. Research now emphasizes broader autoimmune mechanisms, including antibodies against other myelin proteins (e.g., MOG) or glial targets (e.g., AQP4 in neuromyelitis optica). Nonetheless, MBP-derived peptides or degradation products in cerebrospinal fluid (CSF) may serve as biomarkers for active myelin breakdown. Studies on MBP antibodies continue to inform therapeutic strategies aimed at modulating immune responses or promoting remyelination in neurodegenerative diseases.
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